Given the complex challenges of living with cystic fibrosis (CF) and the intense demands it places on Compass case managers (CCMs) at the Cystic Fibrosis Foundation (CFF) who support the CF community, this study explored the integration of positive psychology interventions to enhance CCM well-being. CFF’s Compass program provides crucial support to individuals battling CF, focusing on personalized assistance through insurance, financial, and legal challenges. Despite the invaluable support they provide, CCMs face significant emotional and logistical stresses that can impact their mental health and job satisfaction. This study recommends implementing positive psychology practices to develop and spot character strengths, foster high-quality connections, and support resilience to improve CCMs’ well-being and mitigate the risk of burnout. The implications of these recommendations suggest that such positive psychology interventions are essential for maintaining the health of the Compass workforce by improving CCM subjective well-being through enhanced resilience and satisfaction. This approach underscores the necessity of comprehensive strategies in highly stressful situations where emotional demands and lack of viable positive outcomes are extreme.