The Internet of Medical Things (IoMT) is poised to revolutionize medicine. However, medical device communication, coordination, and interoperability present challenges for IoMT applications due to safety, security, and privacy concerns. These challenges can be addressed by developing an open platform for IoMT that can provide guarantees on safety, security and privacy. As a first step, we introduce OpenICE-lite, a middleware for medical device interoperability that also provides security guarantees and allows other IoMT applications to view/analyze the data in real time. We describe two applications that currently utilize OpenICE-lite, namely (i) a critical pulmonary shunt predictor for infants during surgery; (ii) a remote pulmonary monitoring systems (RePulmo). Implementations of both systems are utilized by the Children’s Hospital of Philadelphia (CHOP) as quality improvements to patient care.