We have numerically investigated the interaction dynamics between two rigid spherical particles moving in a fluid-filled cylinder that is rotating at a constant speed. The cylinder rotation is about a horizontal axis. The particle densities are less than that of the fluid. The numerical procedure employed to solve the mathematical formulation is based on a three-dimensional arbitrary Larangian–Eulerian (ALE), moving mesh finite-element technique, described in a frame of reference rotating with the cylinder. Results are obtained in the ranges of particle Reynolds number, 1