Date of this Version
Hematopoietic stem cells (HSCs) are characterized by their self-renewal potential and ability to differentiate into multiple blood lineages.1,2 They are essential for lifelong blood production and represent 1 of the best-studied somatic stem cell systems.2-4 Several decades of successful bone marrow transplants have demonstrated the therapeutic importance of HSCs.5 Much progress has been made to understand the regulatory network of HSC self-renewal and differentiation.6,7 Several studies suggest that epigenetic mechanisms play an important role in controlling HSC renewal and lineage commitment.8-12 Understanding the regulatory mechanisms of HSC self-renewal and differentiation is important for both basic stem cell biology and improving the quality of stem cell transplantation in clinical settings.
Yu, X., Wu, C., Bhavanasi, D., Wang, H., Gregory, B. D., & Huang, J. (2017). Chromatin Dynamics during the Differentiation of Long-Term Hematopoietic Stem Cells to Multipotent Progenitors. Blood Advances, 1 (14), 887-898. http://dx.doi.org/10.1182/bloodadvances.2016003384
Additional FilesSupplemental Figures_Chromatin dynamics during differentiation.pdf (1552 kB)
F1_Chromatin dynamics during differentiation.jpg (61 kB)
Figure 1_Chromatin dynamics during differentiation.jpg (165 kB)
Figure 2_Chromatin dynamics during differentiation.jpg (132 kB)
Figure 3_Chromatin dynamics during differentiationjpg.jpg (151 kB)
Figure 4_Chromatin dynamics during differentiation.jpg (108 kB)
Date Posted: 14 July 2017
This document has been peer reviewed.