Chromatin Dynamics during the Differentiation of Long-Term Hematopoietic Stem Cells to Multipotent Progenitors

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dc.contributor.authorYu, Xiang
dc.contributor.authorBhavanasi, Dheeraj
dc.contributor.authorWu, Chao
dc.contributor.authorGregory, Brian D
dc.contributor.authorWang, Hong
dc.contributor.authorHuang, Jian
dc.date2023-05-17T17:27:42.000
dc.date.accessioned2023-05-22T12:36:17Z
dc.date.available2023-05-22T12:36:17Z
dc.date.issued2017-06-01
dc.date.submitted2017-07-10T07:25:27-07:00
dc.description.abstractHematopoietic stem cells (HSCs) are characterized by their self-renewal potential and ability to differentiate into multiple blood lineages.1,2 They are essential for lifelong blood production and represent 1 of the best-studied somatic stem cell systems.2-4 Several decades of successful bone marrow transplants have demonstrated the therapeutic importance of HSCs.5 Much progress has been made to understand the regulatory network of HSC self-renewal and differentiation.6,7 Several studies suggest that epigenetic mechanisms play an important role in controlling HSC renewal and lineage commitment.8-12 Understanding the regulatory mechanisms of HSC self-renewal and differentiation is important for both basic stem cell biology and improving the quality of stem cell transplantation in clinical settings.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/5534
dc.legacy.articleid1017
dc.legacy.fields10.1182/bloodadvances.2016003384
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1017&context=biology_papers&unstamped=1
dc.relation.urlhttps://repository.upenn.edu/cgi/viewcontent.cgi?filename=0&article=1017&context=biology_papers&type=additional
dc.relation.urlhttps://repository.upenn.edu/cgi/viewcontent.cgi?filename=1&article=1017&context=biology_papers&type=additional
dc.relation.urlhttps://repository.upenn.edu/cgi/viewcontent.cgi?filename=2&article=1017&context=biology_papers&type=additional
dc.relation.urlhttps://repository.upenn.edu/cgi/viewcontent.cgi?filename=3&article=1017&context=biology_papers&type=additional
dc.relation.urlhttps://repository.upenn.edu/cgi/viewcontent.cgi?filename=4&article=1017&context=biology_papers&type=additional
dc.relation.urlhttps://repository.upenn.edu/cgi/viewcontent.cgi?filename=5&article=1017&context=biology_papers&type=additional
dc.source.beginpage887
dc.source.endpage898
dc.source.issue51
dc.source.issue14
dc.source.journalDepartmental Papers (Biology)
dc.source.journaltitleBlood Advances
dc.source.peerreviewedtrue
dc.source.statuspublished
dc.source.volume1
dc.subject.otherBiology
dc.subject.otherHematology
dc.subject.otherMedical Cell Biology
dc.titleChromatin Dynamics during the Differentiation of Long-Term Hematopoietic Stem Cells to Multipotent Progenitors
dc.typeReport
digcom.contributor.authorisAuthorOfPublication|email:yuxiang1@sas.upenn.edu|institution:University of Pennsylvania|Yu, Xiang
digcom.contributor.authorWu, Chao
digcom.contributor.authorisAuthorOfPublication|email:dheerajb@mail.med.upenn.edu|institution:University of Pennsylvania|Bhavanasi, Dheeraj
digcom.contributor.authorWang, Hong
digcom.contributor.authorisAuthorOfPublication|email:bdgregor@sas.upenn.edu|institution:University of Pennsylvania|Gregory, Brian D
digcom.contributor.authorHuang, Jian
digcom.identifierbiology_papers/51
digcom.identifier.contextkey10407752
digcom.identifier.submissionpathbiology_papers/51
digcom.typereport
dspace.entity.typePublication
relation.isAuthorOfPublication3d5971ce-e176-45b6-bd35-8068ee4e1adb
relation.isAuthorOfPublicationa3c905d4-8143-4ee5-9a43-ad310c691fb2
relation.isAuthorOfPublicationa3c905d4-8143-4ee5-9a43-ad310c691fb2
relation.isAuthorOfPublicationb83aa9d5-202e-44c2-bc44-309bd7bf30b0
relation.isAuthorOfPublication.latestForDiscovery3d5971ce-e176-45b6-bd35-8068ee4e1adb
upenn.schoolDepartmentCenterDepartmental Papers (Biology)
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