Chromatin Dynamics during the Differentiation of Long-Term Hematopoietic Stem Cells to Multipotent Progenitors
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Hematology
Medical Cell Biology
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https://repository.upenn.edu/cgi/viewcontent.cgi?filename=1&article=1017&context=biology_papers&type=additional
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Hematopoietic stem cells (HSCs) are characterized by their self-renewal potential and ability to differentiate into multiple blood lineages.1,2 They are essential for lifelong blood production and represent 1 of the best-studied somatic stem cell systems.2-4 Several decades of successful bone marrow transplants have demonstrated the therapeutic importance of HSCs.5 Much progress has been made to understand the regulatory network of HSC self-renewal and differentiation.6,7 Several studies suggest that epigenetic mechanisms play an important role in controlling HSC renewal and lineage commitment.8-12 Understanding the regulatory mechanisms of HSC self-renewal and differentiation is important for both basic stem cell biology and improving the quality of stem cell transplantation in clinical settings.