Date of this Version
We identified a pedigree of Labrador retrievers (LR) that develop hereditary cataracts between 6 and 18 months of age. In humans, galactokinase deficiency is an autosomal recessive disorder characterized by juvenile onset of cataracts.1 In order to evaluate GALK1 as a candidate gene, we cloned and sequenced the canine GALK1 gene and tested a single nucleotide polymorphism (SNP) in the gene for segregation with cataracts in the LR pedigree.
This is the accepted version of the article which has been published in final form at 10.1111/j.1365-2052.2005.01275.x.
Sidjanin, D. J., McElwee, J. L., Miller, B., & Aguirre, G. D. (2005). Cloning of Canine Galactokinase (GALK1) and Evaluation as a Candidate Gene for Hereditary Cataracts in Labrador Retrievers. Animal Genetics, 36 (3), 265-266. http://dx.doi.org/10.1111/j.1365-2052.2005.01275.x
Date Posted: 06 May 2015
This document has been peer reviewed.