Cloning of Canine Galactokinase (GALK1) and Evaluation as a Candidate Gene for Hereditary Cataracts in Labrador Retrievers

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Departmental Papers (Vet)
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Animal Diseases
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Eye Diseases
Medical Genetics
Ophthalmology
Veterinary Medicine
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Sidjanin, Duska J
McElwee, John L
Miller, Brian
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We identified a pedigree of Labrador retrievers (LR) that develop hereditary cataracts between 6 and 18 months of age. In humans, galactokinase deficiency is an autosomal recessive disorder characterized by juvenile onset of cataracts.1 In order to evaluate GALK1 as a candidate gene, we cloned and sequenced the canine GALK1 gene and tested a single nucleotide polymorphism (SNP) in the gene for segregation with cataracts in the LR pedigree.

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2005-06-01
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Animal Genetics
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