Neuroethics Publications

Neural Activity within Area V1 Reflects Unconscious Visual Performance in a Case of Blindsight

Petya D. Radoeva, University of Pennsylvania
Sashank Prasad, University of Pennsylvania
David H. Brainard, University of Pennsylvania
Geoffrey Karl Aguirre, University of Pennsylvania

Document Type Journal Article

Suggested Citation:
Radoeva, P.D., Prasad, S., Brainard, D.H. and Aguirre, G.K. (2008). Neural Activity within Area V1 Reflects Unconscious Visual Performance in a Case of Blindsight. Journal of Cognitive Neuroscience. Vol. 20(11). pp. 1927-1939.

© 2008 MIT Press
http://www.mitpressjournals.org/loi/jocn

Abstract

Although lesions of the striate (V1) cortex disrupt conscious vision, patients can demonstrate surprising residual abilities within their affected visual field, a phenomenon termed blindsight. The relative contribution of spared ‘‘islands’’ of functioning striate cortex to residual vision, versus subcortical pathways to extrastriate areas, has implications for the role of early visual areas in visual awareness and performance. Here we describe the behavioral and neural features of residual cortical function in Patient M.C., who sustained a posterior cerebral artery stroke at the age of 15 years. Within her impaired visual field, we found preserved visual abilities characteristic of blindsight, including superior detection of motion, and above-chance discrimination of shape, color, and motion direction. Functional magnetic resonance imaging demonstrated a retinotopically organized representation of M.C.’s blind visual field within the lesioned occipital lobe, specifically within area V1. The incongruity of a well-organized cortex and M.C.’s markedly impaired vision was resolved by measurement of functional responses within her damaged occipital lobe. Attenuated neural contrast-response functions were found to correlate with M.C.’s impaired psychophysical performance. These results demonstrate that the behavioral features of blindsight may arise in the presence of residual striate responses that are spatially organized and sensitive to contrast variation.

 

Date Posted: 16 June 2011

This document has been peer reviewed.