The former F.A. Poth Brewing Company at 31st and Jefferson Streets in Brewerytown is one of the last remaining 19th century brewery structures in Philadelphia and a beautiful example of the Rundbogenstil-style industrial architecture designed by architect Otto C. Wolf. This thesis draws upon primary sources, including insurance surveys, maps, promotional pamphlets, and advertisements to map the evolution of the brewery in from its very beginnings to its heyday and subsequent decline, with an emphasis on the ways in which the spatial layout of the site functioned as part of the industrial brewing process. It then examines existing literature on adaptive reuse of industrial buildings and builds on several examples from around the nation of successful brewery revitalization projects. The paper concludes with examining future reuse options for the site and how these uses can best be incorporated into a historic brewery building without compromising its historic integrity as a “master machine.”