Currently, High Field (1.5T) Superconducting MR image-guided needle breast procedures allow the physician only to calculate approximately the location and extent of a cancerous tumor in the compressed patient breast before inserting the needle. It can then become relatively uncertain that the tissue specimen removed during the biopsy actually belongs to the lesion of interest. A new method for guiding clinical breast biopsy is presented, based on a deformable finite element model of the breast. The geometry of the model is constructed from MR data, and its mechanical properties are modeled using a non-linear material model. This method allows imaging the breast without compression before the procedure, then compressing the breast and using the finite element model to predict the tumor’s position during the procedure.