We measured the electronic properties and gas sensing responses of template-grown poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS)-based nanowires. The nanowires had a 'striped' structure (gold–PEDOT/PSS–gold), and were typically 8 µm long (1 µm–6 µm–1 µm for the sections, respectively) and 220 nm in diameter. Single-nanowire devices were contacted with pre-fabricated gold electrodes using dielectrophoretic assembly. A polymer conductivity of 11.5 ± 0.7 S cm−1 and a contact resistance of 27.6 ± 4 kΩ were inferred from measurements on nanowires of varying length and diameter. The nanowire sensors detected a variety of odors, with rapid response and recovery (seconds). The response (ΔR/R) varied as a power law with analyte concentration. The power law exponent was found to increase with the molecular weight of the analyte and as a function of temperature. The detection limits are set by noise intrinsic to the device and are at the ppm level even for very volatile analytes.