Tuning hydrogel properties for applications in tissue engineering

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dc.contributor.authorKhetan, Sudhir
dc.contributor.authorChung, Cindy
dc.contributor.authorBurdick, Jason A.
dc.date2023-05-17T03:23:38.000
dc.date.accessioned2023-05-22T12:08:37Z
dc.date.available2023-05-22T12:08:37Z
dc.date.issued2009-09-03
dc.date.submitted2009-12-11T10:07:03-08:00
dc.description.abstractBiomaterial design is an important component towards tissue engineering applications. There are many parameters that may be adjusted including physical properties (i.e., degradation and mechanics) and chemical properties (e.g., adhesion and cellular interactions). These design components may dictate the success or failure of a tissue engineering approach. Our group is particularly interested in the use of swollen hydrogels as cell carriers. One material that is used to fabricate hydrogels is hyaluronic acid (HA), which is found in many tissues in the body. Here, we show the control over hydrogel degradation, both in the bulk and locally to cells to control both the distribution of extracellular matrix by cells and whether or not a cell spreads in the hydrogels. These signals are important in the final structure and mechanical properties of engineered tissues, and potentially the differentiation of encapsulated stem cells.
dc.description.commentsCopyright 2009 IEEE. Reprinted from: Khetan, Sudhir; Chung, Cindy; Burdick, Jason A., "Tuning hydrogel properties for applications in tissue engineering," Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE , vol., no., pp.2094-2096, 3-6 Sept. 2009 Publisher URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=5332484&isnumber=5332379 This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Pennsylvania's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.
dc.identifier.urihttps://repository.upenn.edu/handle/20.500.14332/2820
dc.legacy.articleid1170
dc.legacy.fulltexturlhttps://repository.upenn.edu/cgi/viewcontent.cgi?article=1170&context=be_papers&unstamped=1
dc.source.issue150
dc.source.journalDepartmental Papers (BE)
dc.source.statuspublished
dc.titleTuning hydrogel properties for applications in tissue engineering
dc.typePresentation
digcom.contributor.authorisAuthorOfPublication|email:khetans@seas.upenn.edu|institution:University of Pennsylvania|Khetan, Sudhir
digcom.contributor.authorisAuthorOfPublication|email:cchung3@seas.upenn.edu|institution:University of Pennsylvania|Chung, Cindy
digcom.contributor.authorisAuthorOfPublication|email:burdick2@seas.upenn.edu|institution:University of Pennsylvania|Burdick, Jason A.
digcom.identifierbe_papers/150
digcom.identifier.contextkey1086139
digcom.identifier.submissionpathbe_papers/150
digcom.typeconference
dspace.entity.typePublication
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relation.isAuthorOfPublicationf56695b7-9359-4e0f-9eaf-1e9e34bad939
relation.isAuthorOfPublication57dace0f-64da-4035-bdc8-582db7cf0478
relation.isAuthorOfPublication.latestForDiscoveryae7fd75d-b962-4f60-a263-e75b7a14f1aa
upenn.schoolDepartmentCenterDepartmental Papers (BE)
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