The Effect of TMS on Emotion Regulation in Bipolar Disorder

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Interdisciplinary Centers, Units and Projects::Center for Undergraduate Research and Fellowships (CURF)::Fall Research Expo
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Discipline
Psychiatry and Psychology
Subject
Transcranial magnetic stimulation
TMS
Bipolar
Bipolar disorder
Depression
Emotion regulation
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2025-08-30
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Author
Ibrahim, Amir
Sheline, Yvette
Contributor
Makhoul, Walid
Abstract

Bipolar Disorder (BD) is a lifelong condition characterized by extreme shifts in mood, or dysfunctions in emotion regulation. Prior research has shown that emotion regulation is associated with the anterior insula (AI) in the brain, functionally connected to the inferior parietal lobule (IPL). Stimulating the IPL using transcranial magnetic stimulation (TMS), this study aims to understand if TMS can target and improve emotion regulation in BD. Results were collected using various tasks and assessments. Among these measures, the Positive and Negative Affect Schedule (PANAS) measured the capacity in which one can experience positive or negative emotion, and the Balloon Analog Risk Task (BART) was used to assess impulsivity and risk-taking behavior. Participants were divided by active or sham stimulation, and asked to take the assessments before and after TMS sessions. The study is ongoing, but current data suggests that TMS increases positive affect and decreases negative affect, enhancing overall emotional experience. Current data shows little change on impulsivity and risk-taking behavior.

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2025-09-15
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This project was funded by the Penn Undergraduate Research Mentoring (PURM) program.
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