Objectives: The purpose of the study was to compare the shear bond strength of five self-adhesive resin cements used to bond zirconia. Methods: Seventy-two KATANA Zirconia STML (n=12) specimens were sectioned and sintered in an induction furnace (CEREC SpeedFire, Dentsply Sirona, Germany). Specimen surfaces were ground finished with 800 grit silicon carbide abrasive with cooling water and cleaned with ultrasonication in alcohol. Specimens were air-particle abraded with 50 μm aluminum oxide at 2.8 bar pressure. Cylindrical composite resin specimens (2.1 mm in diameter, 3 mm in height) were bonded to the zirconia samples with self-adhesive resin cements Panavia SA Universal (PSA), TheraCem (TCM), SpeedCem 2.0 (SCM), RelyX Unicem 2 (RCM), PermaCem 2.0 (PCM) and dual-cure multi-step composite resin cement Panavia V5 (control, PV5, after application of ceramic primer) following manufacturers’ instructions. A load of 1000 g was applied to the composite cylinders during bonding in an alignment apparatus, then light cured for 80 s. Samples were stored in distilled water at 37° C for 24 h, then subjected to 10,000 thermal cycles. Shear bond strength was determined using a universal testing machine at a crosshead speed of 0.5 mm/min expressed in MPa. The fractured surfaces of specimens were inspected with a stereo microscope and classified as 8 adhesive, cohesive, or mixed failures. One-way ANOVA test and Tukey test were applied for statistical analysis. Results: Shear bond strength values [MPa] were for PSA 8.64 (1.78 SD), TCM 9.05 (2.64 SD), SCM 8.54 (1.92 SD), RCM 7.60 (1.26 SD), PMC 7.59 (1.10 SD) and PV5 9.59 (1.55 SD). One-way ANOVA test revealed no statistically significant differences in shear bond strength between the resin cements tested (p>0.05). Pair wise comparison using Tukey test revealed that the shear bond strength using RCM was statistically lower than that using PV5 (p<0.05). Conclusions: According to the results of this in vitro study, self-adhesive resin cements can achieve shear bond strengths to zirconia that are comparable multi-step resin cements. In routine clinical application, self-adhesive resin cements can be a user- friendly, less technique sensitive alternative for bonding Zirconia restorations following the APC concept.