In recent years, there has been growing interest in the use of granular hydrogels as biomaterials for biomedical applications. Granular hydrogels consist of hydrogel microparticles (i.e., “microgels”) that are tens to hundreds of microns in diameter and packed into a jammed state. This thesis investigates the following central question: how do we best fabricate and design granular hydrogels with modular properties for biomedical applications? To do so, granular hydrogels are made from fragmented hyaluronic acid (HA) microgels and explored for applications in injectable tissue repair, extrusion printing, and cell culture. The material properties are explored with respect to changes in particle design and assembly properties (i.e., microgel shape and size distribution, degree of jamming, intra- and inter-particle crosslinking chemistry, addition of interstitial phase hydrogels) and thoroughly characterized. First, the properties of HA granular hydrogels were characterized as a function of microgel fabrication method (i.e., microfluidic devices, batch emulsions, and mechanical fragmentation by extrusion) towards informed biomaterial design. Heterogeneous and jagged microgels fabricated from extrusion fragmentation yields granular hydrogels with enhanced mechanical moduli and structural integrity compared to spherical microgels fabrications from emulsion-based techniques. Next, the mechanical properties of granular composites were tailored by varying microgel and interstitial matrix compositions and moduli. Granular hydrogel composites consist of microgels are embedded in a crosslinked interstitial matrix, which significantly improves mechanical moduli compared to granular hydrogels without an interstitial matrix. While compressive moduli increased with increasing microgel modulus and interstitial matrix modulus, it was determined that failure properties (i.e., strain and stress) increased by combining softer microgels with stiffer interstitial matrices. Types of crosslinkers (i.e., covalent v. guest-host) as well as degradability were varied in each phase to further understand material properties towards informed biomaterials deign for future applications. Next, injectable and adhesive granular hydrogels with dynamic-covalent interparticle crosslinking were investigated for 3D printing and cell culture applications. Introducing dynamic covalent hydrazone bonds between microgels resulted in significant increases in structural stability while maintaining injectability. Adhesive granular hydrogels were used as a 3D printing ink, where printed structures were immediately stable upon deposition without the need for post-process steps. Further, adhesive granular hydrogels allow for cell invasion through an in vitro spheroid outgrowth assay. This work demonstrates the use of dynamic covalent inter-particle crosslinking to enhance injectable granular hydrogels. Lastly, injectable radiopaque granular hydrogel was fabricated for intervertebral disc repair. Zirconium oxide (ZrO2) nanoparticles were encapsulated into microgels to introduce radiopacity, enabling direct visualization of the hydrogel using clinically-relevant imaging technologies (i.e., x-ray and CT scan). Radiopaque granular hydrogels restored healthy disc mechanics in a degenerative disc rabbit model ex vivo. As a proof-of-concept, the radiopaque granular hydrogel was directly visualized following percutaneous intradiscal delivery in a degenerated goat disc in vivo. Overall, this study demonstrates the great potential of injectable radiopaque granular hydrogels for degenerative disc disease treatment. The use of granular hydrogels for biomedical applications grows each year, and the work in this thesis can help guide material development to advance granular hydrogel biomaterials.