Hydrogels have been widely used as polymeric biomaterials for biomedical applications due to their tunable physicochemical properties and high water content. However, hydrogels are often fabricated via molding into simple shapes that fail to mimic the complicated architectures of native tissues. Light-driven additive manufacturing, particularly digital light processing (DLP), has emerged as a promising 3D printing technique to fabricate objects with personalized design, high resolution, and at a rapid throughput. DLP uses planar light projection to crosslink liquid resin into a solid object in a layer-by-layer manner. This dissertation focuses on development of novel hydrogel resins that can be implemented with DLP for a variety of applications ranging from in vitro 3D disease models to macroporous scaffolds and tissue adhesives. The first section explores the use of DLP to fabricate hydrogel templates for human engineered heart tissues that are leveraged for modeling of cardiac disease (i.e., pathological cardiac hypertrophy). The next section focuses on the development of hydrolytically degradable hydrogels to create scaffolds that exhibit tunable rate of degradation. The latter part of the dissertation addresses the fabrication of mechanically robust hydrogels by introducing interpenetrating networks, polymer chain entanglements, and incorporating hydrogel microparticles. Finally, the dissertation highlights the processing of photoresponsive hydrogels that can be functionalized, stiffened, or softened on demand. Throughout this dissertation, emphasis is placed on incorporating functionalities such as degradation, high mechanical performance (e.g., modulus, toughness), and dynamic responsiveness. These advancements provide unprecedented access to highly tunable DLP printed hydrogels with the ability to mimic biological processes during tissue morphogenesis and disease.