Twisted photons, carrying spin and orbital angular momentum (OAM) in an unbounded-dimensional Hilbert space, has recently sparked significant interest, leading to the discovery of new physics in both classical and quantum optics, furthering our understanding and incubating applications in classical and quantum communication. At the heart of this emerging field is the requirement for versatile, efficient, and robust generation of novel photonic spin-orbit states involving both spin and OAM degrees of freedom (DoFs). However, so far, the generation and manipulation of spin–orbit photons have primarily relied on free-space bulk optics, which, due to their lack of compactness and stability, are unsuitable for large-scale applications. In this work, we address this challenge by dynamically generating and manipulating the photonic spin-orbit states in both integrated microlaser and single photon source systems, leveraging non-Hermitian photonics and chiral quantum optics. We further investigated the generation and control of quantum entanglement between the spin and OAM DoFs of photons via integrated photonic circuits. Moreover, we successfully generated photonic spin-orbit states with intricate Skyrmionic topological structures and demonstrate the robustness of their topological properties during the quantum teleportation process. The integrated spin-orbit control toolbox for various structured photons, combined with the robustness of their topological properties, holds significant potential for developing large-channel capacity, noise-resilient information systems within a unique multidimensional space.