ABSTRACT Objective: This study examined the psychological well-being of women of sub-Saharan African ancestry who wear the Islamic head covering, called hijab (so-called hijabi women) in the United States. The study focused on perceived discrimination, resilience, and psychological well-being of this group. The population under study faced distinctive challenges in the context of intersectionality amidst rising anti-Muslim and anti-immigrant sentiments in the US. Methods: The study is quantitative research, with cross-sectional design. The number of participants is N=155. Data were collected using Google Forms from women 18 years old and above, using the Anti-Muslim Discrimination Scale, Transcultural Resilience Scale and the Psychological (Distress and psychological) Scale. Employing network and convenience sampling approaches, diverse experiences were captured within this demographic group. Data analysis was performed using SPSS 21 and SPSS-Amos for structural equation modeling. Descriptive, bivariate, and multiple regression analyses were used to evaluate the relationships between variables. Results: This study demonstrated that perceived discrimination (Interpersonal and Societal) negatively impacted psychological well-being (Life satisfaction and Distress). The study found a substantial link between societal and interpersonal discrimination (r =0.53, p=0.01). Transcultural resilience mediated between societal discrimination and life-satisfaction. Resilience across cultures was shown to be positively correlated with life satisfaction (B = 0.33, p <.001) but insignificant in predicting distress. As not all hypotheses were proven, the conclusion is that this study was partially supported. Implication: This study filled a critical research gap and provided important objective data and insights to assist in combating discriminatory policies and also identified culturally responsive interventions. The adoption and implementation of the findings will promote equitable and fair practices that uphold human dignities, leading to improved well-being of sub-Saharan African hijabi women living in the United States.