Influenza A virus (IAV) is a common respiratory disease with high mortality and morbidity. Influenza infection can manifest with a range of symptoms: asymptomatic or mild cases to severe life-threatening respiratory failure. In the severest of cases, patients sustain significant inflammation that leads to lung injury. Circadian rhythms, controlled by oscillating clock genes, regulate several physiological processes including hormonal balance, metabolism, cognitive function, and immune system. Circadian rhythms are controlled by oscillating core- clock genes at the molecular level, which control the expressions of downstream targets. Immune responses against IAV are indeed influenced by circadian regulation, as the modification in circadian rhythms can alter the severity of inflammation, effectiveness in viral clearance, and damage to the host. In this article, we explored how the modification in circadian rhythms resulted in varying prognoses against IAV PR/8 infection, as well as how the key cytokine IL-10 influences the intensity of the host immune response.