Diffusion Models for MRI Denoising

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Interdisciplinary Centers, Units and Projects::Center for Undergraduate Research and Fellowships (CURF)::Fall Research Expo
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Biomedical Engineering and Bioengineering
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Radiology
Machine Learning
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2025-10-21
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Gonzalez Varela, Andrea
Rajapakse, Chamith
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Abstract

Magnetic Resonance Imaging (MRI) scans are limited by long acquisition times required for Nyquist-rate sampling, leading to motion artefacts and high costs. This work develops an end-to-end diffusion-based MRI denoising framework to enhance image quality under undersampled conditions. A modified 2D U-Net diffusion model was adapted for complex-valued MRI data, trained using a custom multi-metric loss balancing perceptual and quantitative fidelity. The system efficiently processes large slices via patch-based denoising and achieves stable convergence with improved SSIM and PSNR. The trained denoiser is validated as a standalone model and will next be integrated as a plug-and-play proximal operator in MRI reconstruction.

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2025-09-15
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This project was supported with funding from the Penn Undergraduate Research Mentoring (PURM) program.
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