Assessing Novel Object Recognition in Rodents Wearing a Wireless Recording Neural Prosthetic
Penn collection
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Discipline
Neuroscience and Neurobiology
Subject
Neuroengineering
Neural Prosthetic
Alzheimer's Disease
Auditory stimulation
Neurotechnology
Novel Object Recognition
Spatial Object Recognition
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Abstract
This research project aimed to determine if there is a correlation between the amount of slow-wave sleep received and spatial object recognition memory recall. It was hypothesized that entraining slow-waves through auditory stimulation would improve sleep quality, and likewise improve object-place-based memory. Slow-wave sleep was recorded using a novel wearable neurotechnology developed by the Richardson Lab at Penn Neurosurgery, and memory recall was measured through analysis of video footage of rodents as they navigated a field with familiar and unfamiliar objects. An inconclusive memory effect was observed during the spatial object recognition task prior to treatment, meaning a baseline of rodent memory before applying auditory stimulation has yet to be established. The linear regression model of the slow-wave sleep versus memory recall will be essential to future research using auditory stimulation to enhance memory through sleep activity manipulation, a potential rehabilitative therapy for Alzheimer’s Disease.