Based on a qualitative case study in six arsenic acute villages in southwest Bangladesh, this paper presents the intersectional impact of the arsenic poisoning crisis in rural Bangladesh. Findings indicate that the arsenic poisoning crisis is aggravating existing gender inequalities as well as gender roles and responsibilities. The gender inequalities related to arsenicosis are manifested in the access to health care and in the degree of social stigma: women are the biggest victims, unmarried women in particular. The study shows that multiple axis of oppression as class, disability and age are crucial in determining the magnitude of the arsenic poisoning impacts in rural Bangladesh. Understanding the gendered dynamics in the arsenic poisoning crisis and, in particular its intersectional impact on women informs the debate on disaster management. Consequently, by expanding current knowledge, this case study lays the ground for more comprehensive and gender inclusive policy making in the context of hazardous waterscapes.