While individual hormones have been extensively studied, even in well-defined connectomes, insights from such studies are limited because, in freely behaving animals, neuronal and circuit responses to any modulator are often influenced by parallel factors like co-circulating hormones. The collective action of these modulators may not be predictable from the sum of their individual effects due to non-linear interactions (e.g. second-messenger systems). Hitherto, nothing is known about the impact of naturally occurring, behavior state-specific hormone environments across multiple distinct circuit states with defined connectomes. Therefore, my thesis research focused on elucidating how two behavioral state-specific hormonal environments influence four differently modulated versions (i.e., circuit states) of two feeding-related motor circuits with known connectomes, where cellular and synaptic modifications can be elucidated. In addition to characterizing these hormonal influences, I collaborated with another laboratory to work towards identifying the effective hormone(s), using mass spectrometry, HPLC-separated hemolymph fractions, neurophysiology, and analytical strategies. My work examined behavioral state-dependent (i.e. unfed vs. fed) hormonal tuning (i.e. hormone-rich hemolymph) of four distinct circuit states in the crab Cancer borealis stomatogastric ganglion. This had not been accomplished previously in any system. Resultantly, I extend insights from individual hormonal modulation to the distinct influence of hormonal environments from two behavioral states across multiple circuit states within the same well-defined connectome. Three overarching outcomes emerged from my research: (1) Circuit state-responses can be behavioral state-dependent (e.g. fed hemolymph more reliably elicited G-SIFamide-gastric mill [chewing] rhythms than unfed hemolymph; Chapter 2). (2) Behavioral state-specific hormonal tuning can be circuit state-dependent (e.g. fed hemolymph elicited different pyloric circuit responses between the desensitized G-SIFamide circuit state and the RPCH, proctolin and oxotremorine circuit states; Chapters 3). (3) Hormonal tuning can also be circuit state-independent (e.g. unfed hemolymph had similar effects across the RPCH, proctolin and oxotremorine circuit states; Chapter 3).