This paper gives a thorough analysis of current and past research on the neurodegenerative effects of blast overpressure on military and law enforcement personnel. Chronic neurodegenerative disease has historically been studied among sports such as football and boxing, leading to both pathological and symptomatological findings that have been used as diagnosis tools. The start of war in the Middle East led to a discovery in the same pathological and symptomatological discoveries in military settings. Blast overpressure waves are suspected to be the catalyst attributing to these findings, produced through occupational factors such as weapons. The research analyzed in this paper is used to give a concluding set of general guidelines for prevention practices that can be applied to military and law enforcement training settings. The use of brain proteins as a diagnostic tool for chronic neurodegenerative diseases like CTE is discussed.