Black US women are disproportionately impacted by obesity at all levels of income and education. Persistent disparities in obesity underscore the need to better understand specific obesogenic determinants in this population. It is unclear why traditional protective factors, such as high socioeconomic status (SES), do not attenuate the risk of obesity in Black US women. Using a socioecological framework with an intersectional lens, this dissertation will examine the interactions of place and stigma and their associations with weight status among college educated Black US women via two mechanisms: eating behaviors and weight/shape and body image perceptions. The study examines the workplace environment as a space of socioecological significance for high-SES Black US women, presenting social, cultural, and structural tensions that shape social standing and may influence weight status for this population. This dissertation has three aims: (i) Investigate influences of sociocultural and socioeconomic status in sex and gender differences on obesity prevalence, comorbidities, and treatment; (ii) Explore the relationships between psychosocial stress, stigma, and workplace environment, including workplace racial composition, and their potential influence on obesity-related eating behaviors; (iii) Understand weight and shape perceptions in college educated Black US women who work in predominantly White environments and examine the influence of the work environment in these perceptions. Aim 1 is accomplished in part, through a published review of sex/gender differences in obesity prevalence, comorbidities, and treatment. Aim 2 is addressed using a cross-sectional observational web-based survey. Aim 3 is addressed through a qualitative descriptive study of 20 semi-structured interviews. Results of the survey study (Aim 2) revealed that perceived stress and workplace stress, and contextualized stress were associated with obesogenic eating behaviors. Exploratory findings suggest that workplace racial composition may play a role in these associations. Results from the qualitative study (Aim 3) indicated hypervisibility and impression management in predominantly White work environments influenced perceptions of body perceptions of college educated Black US women. However, participants’ personal perceptions differed outside of the context of the work environment. Overall, the findings of this dissertation contribute to a growing body of research that seeks to acknowledge and address the persistent disparities in obesity for Black US women using an intersectional lens. Our findings demonstrate that there are multifactorial, but addressable ways in which the work environment influences weight status for college educated Black US women.