The current polarized sociocultural and political climate and discourse in the United States demonstrate the importance of understanding our humanity across racial and minoritized groups while fostering deeper cross-cultural relationships. While there has been some research on the state of mental health for Latines in the United States and effective therapeutic interventions offered to date, no studies have taken into consideration coloniality’s impact on social work mental health practices for Latines. This two-paper theoretical and conceptual dissertation aims to identify the ways coloniality exists within clinical social work practices, its impact on Latine mental health, and present how therapists could engage in a ‘decolonial turn’ in practice. Paper one reviews the literature on the current state of Latine mental health within the United States, outlining supportive factors and barriers to effective treatment outcomes. Additionally, this paper examines the literature on coloniality and social work utilizing clinical vignettes to discuss coloniality’s impact on clinical social work practice with Latine clients. The second paper is focused on clinical application by presenting a clinical guidebook for therapists. This guidebook illustrates a decolonial framework to assist in incorporating coloniality in case conceptualization and treatment planning with Latin clients. Paper two utilizes the same clinical vignettes introduced in paper one to illustrate how therapists may work towards a decolonial practice.