The Effect of Perfluorooctanoic Acid on Gestational Diabetes Mellitus/Impaired Glucose Tolerance

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Interdisciplinary Centers, Units and Projects::Center for Undergraduate Research and Fellowships (CURF)::Fall Research Expo
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Data Science
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Epidemiology
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2025-09-28
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Batey, Ashley
Ko, Jennifer
Williams, Kelli
Puvvula, Jagadeesh
Chen, Aimin
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Abstract

Perfluorooctanoic acid (PFOA) is a man-made, persistent containment found in everyday items, drinking water, and food.1 PFOA is suspected to decrease β-cell function, which monitors glucose homeostasis and regulates insulin secretion.1 Pregnant women are more susceptible to insulin resistance due to hormonal imbalance, so proper regulation of insulin and glucose is crucial.2 We hypothesize that PFOA is associated with an increased odds of GDM/IGT in U.S. pregnant women.

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2025-09-15
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This project was supported with funding from the Penn Undergraduate Research Mentoring (PURM) program.
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