This paper explores the security challenges posed by data-intensive applications deployed in cloud environments that span administrative and network domains. We propose a data-centric view of cloud security and discuss data management challenges in the areas of secure distributed data processing, end-to-end query result verification, and cross-user trust policy management. In addition, we describe our current and future efforts to investigate security challenges in cloud data management using the Declarative Secure Distributed Systems (DS2) platform, a declarative infrastructure for specifying, analyzing, and deploying secure information systems.