The physical environment is ubiquitous in our human experience. Research indicates it can be used to positively influence its inhabitants’ behavior, cognition, and emotions to foster well-being. This paper suggests a strengths-based approach to space design with a focus on physical work environments (PWE). PWEs encompass the tangible elements of the workspace that integrate with the work experience. The use of character strengths, or the capacities that enable individuals to thrive, allows for optimal functioning and performance. A task-space-strengths fit, or the match between PWEs intentionally designed to facilitate strengths use and the strengths needed to perform the task at hand, can enhance individual flourishing at work and increase organizational performance. A list of concrete design interventions provides guidance for organizations willing to take a strengths-based approach to designing their PWEs.