Tanaka, Takako I

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  • Publication
    Osteonecrosis of the Jaw in a Patient Taking Once-Yearly Infusion of Zoledronic Acid for Osteopenia
    (2013-11-01) Tanaka, Takako I; Taylor, Charles D
    Osteonecrosis of the jaw (ONJ) is an adverse effect of nitrogen-containing bisphosphonates. Advancing age, intravenous administration of zoledronic acid (ZOL), history of dento-alveolar surgery, and concomitant systemic diseases such as diabetes are known as risk factors for developing ONJ. However, despite numerous studies, the exact pathophysiology remains unclear and management strategies are largely anecdotal. Once-yearly intravenously administered 5 mg ZOL was approved by the US Food and Drug Administration in 2007 for the treatment of osteoporosis and its efficacy with 3 year-regimen had been recently been proven in preventing new clinical fracture. Although occurrences of ONJ have been reported to be rare with this drug administration, available data is very limited and long-term outcomes are lacking. We present a case of ONJ identified in an osteopenic patient with an intermittent but long standing sore mouth related to exposed mandibular bone. Once-yearly infusion of zoledronic acid used in the treatment of osteopenia may contribute to the spontaneous development of ONJ, especially in those presenting with multiple comorbidity factors. This report suggests the importance of health care professionals keeping abreast of new developments in this area and providing appropriate information to their patients.
  • Publication
    Signaling by EphrinB1 and Eph Kinases in Platelets Promotes Rap1 Activation, Platelet Adhesion, and Aggregation via Effector Pathways that Do Not Require Phosphorylation of EphrinB1
    (2004-02-15) Prévost, Nicolas; Woulfe, Donna S; Tognolini, Massimiliano; Tanaka, Takako I
    We have previously shown that platelets express 2 receptor tyrosine kinases, EphA4 and EphB1, and the Eph kinase ligand, ephrinB1m and proposed that transcellular Eph/ephrin interactions made possible by the onset of platelet aggregation promote the further growth and stability of the hemostatic plug. The present study examines how this might occur. The results show that clustering of either ephrinB1 or EphA4 causes platelets to adhere to immobilized firinogen via αIIbβ3. Adhesion occurs more slowly than with adenosine diphosphate (ADP) abd requires phosphatidylinositol 3 (PI3)—kinase and protein kinase C activity but not ephrinB1 phosphorylation. By itself, Eph and ephrin signaling is insufficient to cause aggregation or the binding of soluble fibrinogen, but it can potentiate aggregation initiated by a Ca++ ionophore or by agonists for thrombin and thromboxane receptors. It also enhances Rap1 activation without requiring ADP secretion, ephrinB1 phosphorylation, or the activation of PI3-kinase and Src. From this we conclude that (1) Eph/ephrin signaling enhances the ability of platelet agonists to cause aggregation provided that those agonists can increase cytosolic Ca++; (2) this is accomplished in part by activating Rap1; and (3) these effects require not phosphotyrosine-based interactions with the ephrinB1 cytoplasmic domain.
  • Publication
    A Qualitative Systematic Review of the Association of Sleep Disturbances with Burning Mouth Syndrome: An Overlooked Relationship
    (2021-05-18) Alhendi, Fatmah J; Corby, Patricia; KO, Eugene; Graham, Laurel; Akintoye, Sunday; Tanaka, Takako
    Objectives: To review the relevant literature to assess if patients with burning mouth syndrome (BMS) are more prone to have sleep disturbances than general population. Methods: The literature search for relevant articles was from July 2020 to March 2021. A systematic search of PubMed, Embase, Google Scholar, Cochrane library, Dentistry & Oral Sciences Source, and Scopus was conducted to search for relevant studies. The quality of studies was assessed in accordance with the Joanna Briggs Institute’s guidelines and using the software SUMARI – The System for the Unified Management, Assessment and Review of Information. Confidence in the findings was assessed using the GRADE‐CERQual approach. Results: A total of 1064 studies were initially identified from the search; 6 studies, two cross-sectional and 4 case controls, met the inclusion criteria and were selected for this systematic review. Sleep disturbances was a required outcome measured in selected studies evaluating symptoms of BMS. For studies that were included in the final analyses, BMS was found to relate to several dimensions of sleep including sleep disturbance and duration (n=6), sleep affecting day-time function (n=4), sleep quality (n=6), sleep efficiency (n=4), and ability to fall asleep (n=4). Consistent evidence of moderate confidence found that BMS was associated with greater sleep disturbance, reduced sleep quality, increased time taken to fall asleep, reduced sleep efficiency, and poor day-time function. Whereas evidence of low confidence was found regarding the association of BMS with reduced sleep duration. Conclusions: Although the presented studies could not establish a direct causal relationship between BMS and sleep disturbances, it revealed that sleep disturbance can be a risk factor or/and an aggravator of BMS symptoms. Medications and psychological management strategies to improve sleep may be considered in future research for managing BMS patients.