Chen, Hung-Ching

Email Address
ORCID
Disciplines
Research Projects
Organizational Units
Position
Introduction
Research Interests

Filters

1
20201
1
1
Reset filters

Settings

Search Results

Now showing 1 - 1 of 1
  • Publication
    Optimization of the Synthesis of BNM-III-170 bis-TFA Salt
    (2020-05-05) Chen, Hung-Ching
    There has been growing interest for small molecule CD4 mimetic compounds due to their capability to inhibit the HIV-1 entry and possibility to eradicate infected cells in livings. Certain experiments also prove that a lead compound, BNM-III-170 (+)-1, developed in the laboratory has direct antiviral effect and could sensitize HIV-infected cells toward Antibody-Dependent Cellular Cytotoxicity (ADCC). An efficient and scalable process synthesis for the HIV-1 entry inhibitor BNM-III-170 bis-TFA salt (+)-1 is described herein for further investigations. The synthesis employs a state-of-the-art dynamic-kinetic resolution (DKR) both to generate the stereogenicity and significantly reduce the number of chromatographic separations throughout the synthesis. By taking advantage of some modifications from the first-generation synthesis, along with the low solubility of late stage intermediate, the scale-up synthesis has been greatly improved from a few hundred milligrams in 6.2% yield over a 15- step sequence. Now to proceed on a 20-gram or larger scale in overall 16 steps and in 9.64% yield, requiring only one chromatographic separation.