Stoopler, Eric T
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Publication Pemphigus(2013-10-01) Stoopler, Eric T; Santoro, Frank A; Werth, Victoria PPemphigus vulgaris and paraneoplastic pemphigus are two subtypes of pemphigus that involve the oral mucosa. These autoimmune blistering disorders have antibodies targeted against proteins of keratinocyte adhesion, thereby causing acantholysis. Clinical findings include oral erosions and flaccid cutaneous bullae and erosions. In addition to the clinical exam, diagnostic tests including tissue biopsy, direct and indirect immunofluorescence, and enzyme-linked immunosorbent assays (ELISA) help to establish a diagnosis. Further malignancy workup in patients with suspected paraneoplastic pemphigus is warranted. Retrospective uncontrolled studies suggest that immunosuppressive agents reduce mortality in pemphigus vulgaris and cohort uncontrolled studies of rituximab, a monoclonal antibody against CD20, suggest it is an effective treatment for refractory patients. Ongoing studies will define its role in early disease.Publication An Evaluation of 10 Percent and 20 Percent Benzocaine Gels in Patients With Acute Toothaches: Efficacy, Tolerability and Compliance With Label Dose Administration Directions(2013-05-01) Hersh, Elliot V; Kuperstein, Arthur S; Stoopler, Eric T; Ciancio, Sebastian G; Moore, Paul A; Boynes, Sean G; Levine, Steven C; Casamassimo, Paul; Leyva, Rina; Mathew, Tanya; Shibly, Othman; Creighton, Paul; Jeffers, Gary E; Corby, Patricia M. A; Turetzky, Stanley N; Papas, Athena; Wallen, Jillian; Idzik-Starr, Cynthia; Gordon, Sharon MBackground The authors evaluated the efficacy and tolerability of 10 percent and 20 percent benzocaine gels compared with those of a vehicle (placebo) gel for the temporary relief of toothache pain. They also assessed the compliance with the label dose administration directions on the part of participants with toothache pain. Methods Under double-masked conditions, 576 participants self-applied study gel to an open tooth cavity and surrounding oral tissues. Participants evaluated their pain intensity and pain relief for 120 minutes. The authors determined the amount of gel the participants applied. Results The responders’ rates (the primary efficacy parameter), defined as the percentage of participants who had an improvement in pain intensity as exhibited by a pain score reduction of at least one unit on the dental pain scale from baseline for two consecutive assessments any time between the five- and 20-minute points, were 87.3 percent, 80.7 percent and 70.4 percent, respectively, for 20 percent benzocaine gel, 10 percent benzocaine gel and vehicle gel. Both benzocaine gels were significantly (P ≤ .05) better than vehicle gel; the 20 percent benzocaine gel also was significantly (P ≤ .05) better than the 10 percent benzocaine gel. The mean amount of gel applied was 235.6 milligrams, with 88.2 percent of participants applying 400 mg or less. Conclusions Both 10 percent and 20 percent benzocaine gels were more efficacious than the vehicle gel, and the 20 percent benzocaine gel was more efficacious than the 10 percent benzocaine gel. All treatments were well tolerated by participants. Practical Implications Patients can use 10 percent and 20 percent benzocaine gels to temporarily treat toothache pain safely.Publication Oral Lichen Planus(2012-10-02) Stoopler, Eric T; Sollecito, Thomas PPublication Human Papillomavirus Lesions of the Oral Cavity(2011-01-01) Stoopler, Eric T; Balasubramanlam, RameshPublication Desquamative Gingivitis: Early Presenting Symptom of Mucocutaneous Disease(2003-01-01) Stoopler, Eric T; Sollecito, Thomas P; DeRossi, Scott SDesquamation of the gingiva is a sign that may be encountered in clinical practice. Various diseases can affect the gingival tissues. Mild desquamation that is localized may be associated with mechanical irritation or induced by trauma. Moderate to severe generalized desquamation associated with ulceration and erythema may be indicative of a more serious systemic condition. Although often overlooked, mucocutaneous diseases frequently present with gingival desquamation as an early presenting symptom. The most common mucocutaneous diseases that affect the oral cavity are lichen planus, pemphigus, and mucous membrane pemphigoid. This article reviews the etiology, signs and symptoms, and therapies for these disorders. Increased knowledge of mucocutaneous diseases can help the clinician recognize these disorders and enable the patient to receive appropriate therapy.Publication Temporomandibular Disorders(2013-03-05) Stoopler, Eric T; Sollecito, Thomas PPublication Extensive Pneumatization of the Temporal Bone and Articular Eminence: An Incidental Finding in a Patient With Facial Pain. Case Report and Review of Literature(2003-01-01) Stoopler, Eric T; Pinto, Andres A; Stanton, David C; Mupparapu, Muralidhar; Sollecito, Thomas PA 53-year-old Caucasian female presented to the Oral Medicine Department at the hospital of the University of Pennsylvania for consultation regarding facial pain. A panoramic radiograph revealed multilocular radiolucencies in the right articular eminence. A CT scan was then performed, and the radiolucencies were determined to be pneumatization of the articular eminence.Publication Household Laundry Detergent as a Possible Cause of Oral Lichenoid Lesions(2013-08-22) Stoopler, Eric T; Nadeau, ChristineOral lichenoid lesions (OLLs) are a diverse group of disorders that may be attributed to an autoimmune etiology, underlying systemic disease, or in association with an identifiable causative agent, such as a medication, food product, or dental material. OLLs commonly present with striae, erythema, and/or ulceration on affected oral mucosa and can be symptomatic. The aim of this report is to describe a case of OLLs that were believed to be attributed to use of household laundry detergent to clean an oral occlusal appliance.Publication Glossitis Secondary to Vitamin B12 Deficiency Anemia(2013-09-03) Stoopler, Eric T; Kuperstein, Arthur SPublication Pregnancy Gingivitis and Pregnancy Tumour(2012-06-01) Stoopler, Eric T; Kuperstein, Arthur S