The Requirement of p53 in Oral MSC differentiation Which Leads to Kaposi’s Sarcoma

Loading...
Thumbnail Image
Degree type
MSOB (Master of Science in Oral Biology)
Graduate group
Discipline
Subject
p53 in Kaposi Sarcoma
p53
mesenchymal stem cell
Kaposi Sarcoma
KSHV
Dentistry
Funder
Grant number
License
Copyright date
Distributor
Related resources
Contributor
Abstract

P53 is considered one of the most important defense proteins against cancer.Although the p53 mutation is associated with many cancers, its mutation is never found in Kaposi’s sarcoma (KS), raising a possibility that functional p53 may play a role in KS development. To assess the role of p53 in Kaposi’s sarcoma tumor, shRNA-mediated gene silencing was used to knockdown p53 expression. We examined Kaposi’s sarcoma-associated herpesvirus (KSHV)-infected periodontal ligaments stem cells (PDLSC) for osteogenic differentiation and endothelial angiogenesis, and we observed noticeable decreases in osteogenic differentiation and angiogenesis when p53 expression was knocked down in KSHV-infected PDLSCs by p53 specific shRNA. The results suggest that p53 plays an essential role in sarcoma development of KSHV infected mesenchymal stem cells.

Advisor
Yan Yuan, PhD
Date of degree
2016-08-01
Date Range for Data Collection (Start Date)
Date Range for Data Collection (End Date)
Digital Object Identifier
Series name and number
Volume number
Issue number
Publisher
Publisher DOI
Journal Issue
Comments
Recommended citation