Departmental Papers (Dental)

 
Penn Dental Medicine views scholarship as a central component of excellence in instruction and patient care and places a high priority on research. The School’s research enterprise spans scientific disciplines to translate new knowledge into clinical therapies that positively impact our understanding of oral disease and advance patient care.

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Submissions from 2007

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A Novel Mode of Action for a Microbial-Derived Immunotoxin: The Cytolethal Distending Toxin Subunit B Exhibits Phosphatidylinositol 3,4,5-Triphosphate Phosphatase Activity, Bruce J. Shenker; Mensur Dlakic´,; Lisa Walker; Dave Besack; Eileen Jaffe; and Ed LaBelle

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Chloroplast Vector Systems for Biotechnology Applications, Dheeraj Verma and Henry Daniell

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Nicotine Induces Hypoxia-Inducible Factor-1AExpression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor ^Mediated Signaling Pathways, Qunzhou Zhang, Xudong Tang, Zuo-feng Zhang, Rita Velikina, Shihong Shi, and Anh D. Le

Submissions from 2006

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Pegvisomant for the Treatment of Gsp-Mediated Growth Hormone Excess in Patients with McCune-Albright Syndrome, Sunday O. Akintoye, Marilyn H. Kelly, Beth Brillante, Natasha Cherman, Sarah Turner, John A. Butman, Pamela G. Robey, and Michael T. Collins

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The Complete Chloroplast Genome Sequence of Citrus Sinensis (L.) Osbeck var 'Ridge Pineapple': Organization and Phylogenetic Relationships to Other Angiosperms, Michael G. Bausher, Nameirakpam D. Singh, Seung-Bum Lee, Robert K. Jansen, and Henry Daniell

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Isolation of Membrane Rafts and Signaling Complexes, Kathleen Boesze-Battaglia

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Cholesterol-Rich Membrane Microdomains Mediate Cell Cycle Arrest Induced by Actinobacillus Actinomycetemcomitans Cytolethal-Distending Toxin, Kathleen Boesze-Battaglia, Dave Besack, Terry McKay, Ali Zekavat, Kelly Jordan-Sciutto, and Bruce J. Shenker

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Cholesterol-Rich Membrane Microdomains Mediate Cell Cycle Arrest Induced by Actinobacillus Actinomycetemcomitans Cytolethal-Distending Toxin, Kathleen Boesze-Battaglia, Dave Besack, Terry McKay, Ali Zekavat, Linda Otis, Kelly Jordan-Sciutto, and Bruce Shenker

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Experimental Study on the Acellular Demal Matrix Graft for the Root Coverage in Dog, Min-Young Cho, Seoung-Ho Lee, Keum-Ah Han, Jun-Young Lee, Hyeran H. Jeon, Na-Ra Kang, and Myung-Rae Kim

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The Effect of Ca-P Coated Bovine Bone Mineral on Bone Regeneration around Dental Implant in Dogs, Su-Yeon Cho, Hyeran H. Jeon, Sun-Kyoung Lee, Seoung-Ho Lee, Jun-Young Lee, and Keum-Ah Han

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Chondrocytes Utilize a Cholesterol-Dependent Lipid Translocator to Externalize Phosphatidylserine, Monika Damek-Poprawa, Ellis Golub, Linda Otis, Gerald Harrison, Christine Phillips, and Kathleen Boesze-Battaglia

Actinobacillus Actinomycetemcomitans Leukotoxin Requires Lipid Microdomains for Target Cell Cytotoxicity, Karen P. Fong, Cinthia M.F. Pacheco, Linda L. Otis, Somesh Baranwal, Irene R. Kieba, Gerald Harrison, Elliot V. Hersh, Kathleen Boesze-Battaglia, and Edward T. Lally

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Actinobacillus Actinomycetemcomitans Leukotoxin Requires Lipid Microdomains for Target Cell Cytotoxicity, Karen P. Fong, Cinthia M.F. Pacheco, Linda T. Otis, Samesh Baranwal, Irene R. Keiba, Gerald Harrison, Elliot V. Hersh, Kathleen Boesze-Battaglia, and Edward T. Lally

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Phylogenetic Analyses of Vitis (Vitaceae) Based on Complete Chloroplast Genome Sequences: Effects of Taxon Sampling and Phylogenetic Methods on Resolving Relationships Among Rosids, Robert K. Jansen, Charalambos Kaittanis, Christopher Saski, Seung-Bum Lee, Jeffrey Tomkins, Andrew J. Alverson, and Henry Daniell

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The Complete Chloroplast Genome Sequence of Gossypium Hirsutum: Organization and Phylogenetic Relationships to Other Angiosperms, Seung-Bum Lee, Charalambos Kaittanis, Robert K. Jansen, Jessica B. Hostetler, Luke J. Tallon, Christopher D. Town, and Henry Daniell

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Receptor-Mediated Oral Delivery of a Bioencapsulated Green Fluorescent Protein Expressed in Transgenic Chloroplasts Into the Mouse Circulatory System, Arati Limaye, Vijay Koya, Mohtashem Samsam, and Henry Daniell

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Diabetes Enhances Periodontal Bone Loss Through Enhanced Resorption and Diminished Bone Formation, Rongkun Liu, Harbinder S. Bal, Tesfahun Desta, Nanarao Krothapalli, Monaf Alyassi, Qingxian Luan, and Dana T. Graves

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Complete Plastid Genome Sequence of Daucus Carota: Implications for Biotechnology and Phylogeny of Angiosperms, Tracey Ruhlman, Seung-Bum Lee, Robert K. Jansen, Jessica B. Hostetler, Luke J. Tallon, Christopher D. Town, and Henry Daniell

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A Membrane Defect in the Pathogenesis of the Smith-Lemli-Opitz Syndrome, Thomas N. Tulenko, Kathleen Boeze-Battaglia, R. P. Mason, G. S. Tint, R. D. Steiner, W. E. Conner, and E. F. Labelle

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Distinct roles of Ca2+ mobilization and G protein usage on regulation of Toll-Like Receptor Function in Human and Murine Mast Cells, Asifa K. Zaidi, Elden Thangam, and Hydar Ali

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Green Tea Extract and (−)-Epigallocatechin-3-Gallate Inhibit Mast Cell-Stimulated Type I Collagen Expression in Keloid Fibroblasts via Blocking PI-3K/Akt Signaling Pathways, Qunzhou Zhang, A Kelly Paul, Lina Wang, Samuel W. French, Xudong Tang, Hai S. Duong, Diana V. Messadi, and Anh D. Le

Submissions from 2005

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The Role of Cholesterol in Rod Outer Segment Membranes, Arlene D. Albert and Kathleen Boesze-Battaglia

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The Role of Cholesterol in Rod Outer Segment Membranes, Arlene D. Albert and Kathleen Boesze-Battaglia

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The Role of Cholesterol in Rod Outer Segment Membranes, Arlene D. Albert and Kathleen Boesze-Battaglia

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Anaphylatoxin C3a Receptors in Asthma, Hydar Ali and Reynold A. Panettieri Jr.

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Characterization of Point Mutations in the cdtA Gene of the Cytolethal Distending Toxin of Actinobacillus Actinomycetemcomitans, Linsen Cao, Alla Volgina, Chuang-ming Huang, Johnathan M. Korostoff, and Joseph M. DiRienzo

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Characterization of Point Mutations in the cdtA Gene of the Cytolethal Distending Toxin of Actinobacillus Actinomycetemcomitans, Linsen Cao, Alla Volgina, Chuang-ming Huang, Jonathan Korostoff, and Joseph M. DiRienzo

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Characterization of Point Mutations in the cdtA Gene of the Cytolethal Distending Toxin of Actinobacillus Actinomycetemcomitans, Linsen Cao, Alla Volgina, Chuang-ming Huang, Jonathan Korostoff, and Joseph M. DiRienzo

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NF-κB Activation in Human Dental Pulp Stem Cells by TNF and LPS, J. Chang; C. Zhang; N. Tani-Ishii; S. Shi; and C. Y, Wang

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A Novel Tetraspanin Fusion Protein, Peripherin-2, Requires a Region Upstream of the Fusion Domain for Activity, Monika Damek-Poprawa, Jennifer Krouse, Cheryl Gretzula, and Kathleen Boesze-Battaglia

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Breakthrough in Chloroplast Genetic Engineering of Agronomically Important Crops, Henry Daniell, Shashi Kumar, and Nathalie Dufourmantel

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A Novel 3-Dimensional Culture System as an In Vitro Model for Studying Oral Cancer Cell Invasion, Hai S. Duong, Anh D. Le, Qunzhou Zhang, and Diana V. Messadi

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Association of a Novel High Molecular Weight, Serine-Rich Protein (SrpA) with Fibril-Mediated Adhesion of the Oral Biofilm Bacterium Streptococcus Cristatus, P. S. Handley, F. F. Correia, K. Russell, B. Rosan, and J. M. DiRienzo

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Differential Effect of the Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans on Co-Cultures of Human Oral Cells, Philip Kang, Johnathan M. Korostoff, Alla Volgina, Wojciech Grzesik, and Joseph M. DiRienzo

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Differential Effect of the Cytolethal Distending Toxin of Actinobacillus Actinomycetemcomitans on Co-Cultures of Human Oral Cells, Philip Kang, Jonathan Korostoff, Alla Volgina, Wojciech Grzesik, and Joseph M. DiRienzo

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Anxiety Control and Periodontal Practice, Seoung-Ho Lee, Jun-Young Lee, Hyeran H. Jeon, and Gum-Aha Han

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Characterization of Heterologous Multigene Operons in Transgenic Chloroplasts. Transcription, Processing, and Translation1, Tania Quesada-Vargas, Oscar N. Ruiz, and Henry Daniell

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Engineering Cytoplasmic Male Sterility via the Chloroplast Genome by Expression of β-Ketothiolase1, Oscar N. Ruiz and Henry Daniell

Submissions from 2004

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C3a Enhances Nerve Growth Factor-Induced NFAT Activation and Chemokine Production in a Human Mast Cell Line, HMC-1, Jasimuddin Ahamed, Rampura T. Venkatesha, E. Berla Thangam, and Hydar Ali

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Enhanced Translation of a Chloroplast-Expressed RbcS Gene Restores Small Subunit Levels and Photosynthesis in Nuclear RbcS Antisense Plants, Amit Dhingra, Archie R. Portis Jr., and Henry Daniell

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Enhanced translation of a chloroplast-expressed RbcS gene restores small subunit levels and photosynthesis in nuclear RbcS antisense plants, Amit Dhingra, Archie R. Portis, and Henry Daniell

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Plastid-Expressed Betaine Aldehyde Dehydrogenase Gene in Carrot Cultured Cells, Roots, and Leaves Confers Enhanced Salt Tolerance1, Shashi Kumar, Amit Dhingra, and Henry Daniell

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Stable Transformation of the Cotton Plastid Genome and Maternal Inheritance of Transgenes, Shashi Kumar, Amit Dhingra, and Henry Daniell

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Signaling by EphrinB1 and Eph Kinases in Platelets Promotes Rap1 Activation, Platelet Adhesion, and Aggregation via Effector Pathways that Do Not Require Phosphorylation of EphrinB1, Nicolas Prévost, Donna S. Woulfe, Massimiliano Tognolini, and Takako I. Tanaka

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Uncoupling of photoreceptor peripherin/rds fusogenic activity f0rom Biosynthesis, Subunit Assembly, and Targeting. A Potential Mechanism for Pathogenic Effects, Linda M. Ritter, Kathleen Boesze-Battaglia, Beatrice M. Tam, Orson L. Moritz, Nidhi Khattree, Shu-Chu Chen, and Andrew F. X. Goldberg

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Uncoupling of Photoreceptor Peripherin/rds Fusogenic Activity from Biosynthesis, Subunit Assembly, and Targeting A POTENTIAL MECHANISM FOR PATHOGENIC EFFECTS*, Linda M. Ritter, Nidhi Khattree, Shu-Chu Chen, Andrew F.X. Goldberg, Kathleen Boesze-Battaglia, Beatrice M. Tam, and Orson L. Moritz

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Role of Leukotriene B4 Receptors in the Development of Atherosclerosis: Potential Mechanisms, Krishnaprasad Subbarao, Venkatakrishna R. Jala, Steven Mathis, Hydar Ali, Michael T. Tseng, and Bodduluri Haribabu

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Platelet-Activating Factor-Induced Chemokine Gene Expression Requires NF-κB Activation and Ca2+/calcineurin Signaling Pathways: Inhibition by Receptor Phosphorylation and β-Arrestin Recruitment, Rampura T. Venkatesha, Jasimuddin Ahamed, Christopher Nuesch, Asifa K. Zaidi, and Hydar Ali

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Metabolic Engineering of the Chloroplast Genome Using the Echerichia coli ubiC Gene Reveals That Chorismate Is a Readily Abundant Plant Precursor for p-Hydroxybenzoic Acid Biosynthesis1, Paul V. Viitanen, Andrew L. Devine, Muhammad Sarwar Khan, Deborah L. Deuel, Drew E. Van Dyk, and Henry Daniell

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Expression of Bacillus Anthracis Protective Antigen in Transgenic Chloroplasts of Tobacco, a Non-Food/Feed Crop, Jennifer Watson, Vijay Koya, Stephen H. Leppla, and Henry Daniell

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Treatment With siRNA and Antisense Oligonucleotides Targeted to HIF-1α Induced Apoptosis in Human Tongue Squamous Cell Carcinomas, Qunzhou Zhang, Zuo-Feng Zhang, Jian Y. Rao, Denry J. Sato, Jimmy Brown, Diana V. Messadi, and Anh D. Le

Submissions from 2003

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A Soluble Peripherin/Rds C-Terminal Polypeptide Promotes Membrane Fusion and Changes Conformation Upon Membrane Association, Kathleen Boesze-Battaglia, Andrew F.X. Goldberg, Janice Dispoto, and Madan Katragadda

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A Soluble Peripherin/Rds C-Terminal Polypeptide Promotes Membrane Fusion and Changes Conformation Upon Membrane Association, Kathleen Boesze-Battaglia, Andrew F.X. Goldberg, Janice Dispoto, Madan Katragadda, Gregory Cesarone, and Arlene D. Albert

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A Soluble Peripherin/Rds C-Terminal Polypeptide Promotes Membrane Fusion and Changes Conformation Upon Membrane Association, Kathleen Boesze-Battaglia, Andrew F.X. Goldberg, Janice Dispoto, Madan Katragadda, Gregory Cesarone, and Arlene D. Albert

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A Chloroplast Transgenic Approach to Hyper-Express and Purify Human Serum Albumin, a Protein Highly Susceptible to Proteolytic Degradation, Alicia Fernández-San Millán, Angel Mingo-Castel, Michael Miller, and Henry Daniell

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Extensive Pneumatization of the Temporal Bone and Articular Eminence: An Incidental Finding in a Patient With Facial Pain. Case Report and Review of Literature, Eric T. Stoopler, Andres A. Pinto, David C. Stanton, Muralidhar Mupparapu, and Thomas P. Sollecito

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Desquamative Gingivitis: Early Presenting Symptom of Mucocutaneous Disease, Eric T. Stoopler, Thomas P. Sollecito, and Scott S. DeRossi

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Increased Plasminogen Activator Inhibitor-1 in Keloid Fibroblasts May Account for Their Elevated Collagen Accumulation in Fibrin Gel Cultures, Tai-Lan Tuan, Huayang Wu, Eunice Y. Huang, Sheree S. N. Chong, Walter Luag, Diana Messadi, Paul Kelly, and Anh Le

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Mechanisms of Hypoxic Regulation of Plasminogen Activator Inhibitor-1 Gene Expression in Keloid Fibroblasts, Qunzhou Zhang, Yidi Wu, David K. Ann, Diana V. Messadi, Tai-Lan Tuan, A. Paul Kelly, Charles N. Bertolami, and Anh D. Le

Submissions from 2002

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Distinct Roles of Receptor Phosphorylation, G Protein Usage, and Mitogen-Activated Protein Kinase Activation on Platelet Activating Factor-Induced Leukotriene C4 Generation and Chemokine Production, Jasimuddin Ahamed and Hydar Ali

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Characterization of gsp-Mediated Growth Hormone Excess in the Context of McCune-Albright Syndrome, S. O. Akintoye, C. Chebli, S. Booher, P. Feuillan, H. Kushner, and D. Leroith

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Association of a Photoreceptor-specific Tetraspanin Protein, ROM-1, with Triton X-100-resistant Membrane Rafts from Rod Outer Segment Disk Membranes, Kathleen Boesze-Battaglia, Janice Dispoto, and Mary Anne Kahoe

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Association of a Photoreceptor-Specific Tetraspanin Protein, ROM-1, with Triton X-100-Resistant Membrane Rafts from Rod Outer Segment Disk Membranes, Kathleen Boesze-Battaglia, Janice Dispoto, and Mary Anne Kahoe

Photoreceptor renewal: A role for peripherin/rds, Kathleen Boesze-Battaglia and Andrew F.X. Goldberg

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Photoreceptor Renewal: A Role for Peripherin/rds, Kathleen Boesze-Battaglia and Andrew F.X. Goldberg

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A Peptide Analogue to a Fusion Domain Within Photoreceptor Peripherin/rds Promotes Membrane Adhesion and Depolarization, Kathleen Boesze-Battaglia, Frank P. Stefano, Madeline Fenner, and Andrew A. Napoli Jr.

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Molecular Strategies for Gene Containment in Transgenic Crops, Henry Daniell

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Multigene Engineering: Dawn of an Exciting New Era in Biotechnology, Henry Daniell and Amit Dhingra

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Milestones in Chloroplast Genetic Engineering: an Environmentally Friendly Era in Biotechnology, Henry Daniell, Muhammad S. Khan, and Lori Allison

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Detection of Cytolethal Distending Toxin Activity and cdt Genes in Actinobacillus Actinomycetemcomitans Isolates From Geographically Diverse Populations, A. S. Fabris, J. M. DiRienzo, M. Wïkstrom, and M.P. A. Mayer

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Functional Studies of the Recombinant Subunits of a Cytolethal Distending Holotoxin, Xiangqun Mao and Joseph M. DiRienzo

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Deletional Analysis of the rod Photoreceptor Cell Peripherin/RDS Carboxy-Terminal Region, Susan Muller-Weeks, Kathleen Boesze-Battaglia, and Catherine Fitzgerald

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Deletional Analysis of the Rod Photoreceptor Cell Peripherin/RDS Carboxy-Terminal Region, Susan Muller-Weeks, Kathleen Boesze-Battaglia, and Catherine Fitzgerald

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Heterologous Expression of WT and Mutant Photoreceptor Peripherin/rds in Madin Darby Canine Kidney Cells: an Assessment of Fusogenic Function, Frank P. Stefano, Jennifer Krouse, Peter Marta, and Kathleen Boesze-Battaglia

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Heterologous Expression of wt and Mutant Photoreceptor Peripherin/rds in Madin Darby Canine Kidney Cells: An Assessment of Fusogenic Function, Frank P. Stefano, Jennifer Krouse, Peter Marta, and Kathleen Boesze-Battaglia

Submissions from 2001

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Cutting Edge: Differential Regulation of Chemoattractant Receptor-Induced Degranulation and Chemokine Production by Receptor Phosphorylation, J. Ahamed, B. Haribabu, and H. Ali

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Expression of the Native Cholera Toxin B Subunit Gene and Assembly as Functional Oligomers in Transgenic Tobacco Chloroplasts, Henry Daniell, Seung-Bum Lee, Tanvi Panchal, and Peter O. Wiebe

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Medical Molecular Farming: Production of Antibodies, Biopharmaceuticals and Edible Vaccines in Plants, Henry Daniell, Stephen J. Streatfield, and Keith Wycoff

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Expression of an Antimicrobial Peptide via the Chloroplast Genome to Control Phytopathogenic Bacteria and Fungi, Gerald DeGray, Kanniah Rajasekaran, Franzine Smith, John Sanford, and Henry Daniell

Submissions from 2000

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Chemokine Production by G Protein-Coupled Receptor Activation in a Human Mast Cell Line: Roles of Extracellular Signal-Regulated Kinase and NFAT, H. Ali, J. Ahamed, C. Hernandez-Munain, J. L. Baron, M. S. Krangel, and D. D. Patel

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Fusion Between Retinal Rod Outer Segment Membranes and Model Membranes: Functional Assays and Role for Peripherin/rds, Kathleen Boesze-Battaglia

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Fusion Between Retinal Rod Outer Segment Membranes and Model Membranes: Functional Assays and Role for Peripherin/rds, Kathleen Boesze-Battaglia

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A Peptide Analogue to a Fusion Domain Within Photoreceptor Peripherin/rds Promotes Membrane Adhesion and Depolarization, Kathleen Boesze-Battaglia, Frank P. Stefano, Madeline Fenner, and Andrew A. Napoli Jr.

Submissions from 1999

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Chemoattractant Receptor Cross-Desensitization, Hydar Ali, Ricardo M. Richardson, Bodduluri Haribabu, and Ralph Snyderman

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Chemoattractant Receptors Activate Distinct Pathways for Chemotaxis and Secretion. Role of G-Protein Usage, Bodduluri Haribabu, Doncho V. Zhelev, Bryan C. Pridgen, Ricardo M. Richardson, Hydar Ali, and Ralph Snyderman

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Overexpression of the Bacillus Thuringiensis (Bt) Cry2Aa2 Protein in Chloroplasts Confers Resistance to Plants Against Susceptible and Bt-resistant Insects, Madhuri Kota, Henry Daniell, Sam Varma, Stephen F. Garczynski, Fred Gould, and William J. Moar

Submissions from 1998

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Differential Regulation of Formyl Peptide and Platelet-Activating Factor Receptors: Role of Phospholipase Cβ3 Phosphorylation by Protein Kinase A, Hydar Ali, Silvano Sozzani, Ian Fisher, Alastair J. Barr, Ricardo M. Richardson, Bodduluri Haribabu, and Ralph Snyderman

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Opiates Transdeactivate Chemokine Receptors: δ and μ Opiate Receptor- Mediated Heterologous Desensitization, M. C. Grimm, A. Ben-Baruch, D. D. Taub, O.M. Z. Howard, J. H. Resau, J. M. Wang, H. Ali, R. Richardson, R. Snyderman, and J. J. Oppenheim

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Epithelial Cell Invasion by Actinobacillus Actinomycetemcomitans Strains From Restriction Fragment-Length Polymorphism Groups Associated With Juvenile Periodontitis or Carrier Status, G. Lépine, S. Caudry, J. M. DiRienzo, and R. P. Ellen

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Multiple Signaling Pathways of Human Interleukin-8 Receptor A: Independent Regulation by Phosphorylation, Ricardo M. Richardson, Hydar Ali, Bryan C. Pridgen, Bodduluri Haribabu, and Ralph Snyderman

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Differential Cross-Regulation of the Human Chemokine Receptors CXCR1 and CXCR2. Evidence for Time-Dependent Signal Generation, Ricardo M. Richardson, Bryan C. Pridgen, Bodduluri Haribabu, Hydar Ali, and Ralph Snyderman

Submissions from 1997

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Role of Phospholipase Cβ3 Phosphorylation in the Desensitization of Cellular Responses to Platelet-Activating Factor, Hydar Ali, Ian Fisher, Bodduluri Haribabu, Ricardo M. Richardson, and Ralph Snyderman

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Regulation of Human Chemokine Receptors CXCR4: Role of Phosphorylation in Desensitization and Internalization, Bodduluri Haribabu, Ricardo M. Richardson, Ian Fisher, Silvano Sozzani, Stephen C. Peiper, Richard Horuk, Hydar Ali, and Ralph Snyderman

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Chemoattractant Receptor-Induced Phosphorylation of L-Selectin, Bodduluri Haribabu, Douglas A. Steeber, Hydar Ali, Ricardo M. Richardson, Ralph Snyderman, and Thomas F. Tedder

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Multiple Signaling Pathways of Human Interleukin-8 Receptor A: Independent Regulation by Phosphorylation, Ricardo M. Richardson, Hydar Ali, Bryan C. Pridgen, and Ralph Snyderman

Submissions from 1996

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Thrombin Primes Responsiveness of Selective Chemoattractant Receptors at a Site Distal to G Protein Activation, Hydar Ali, Eric D. Tomhave, Ricardo M. Richardson, and Bodduluri Haribabu

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Cross-Desensitization Among Receptors for Platelet Activating Factor and Peptide Chemoattractants: Evidence for Independent Regulatory Pathways, Ricardo M. Richardson, Bodduluri Haribabu, Hydar Ali, and Ralph Snyderman

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Comparison of Randomly Cloned and Whole Genomic DNA Probes for the Detection of Porphyromonas Gingivalis and Bacteroides Forsythus, M. Wong, J. M. DiRienzo, C. H. Lei, and M. A. Listgarten

Submissions from 1995

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Insertional Inactivation of Binding Determinants of Streptococcus Crista CC5A Using Tn916, F. F. Correia, J. M. DiRienzo, R. J. Lamont, and C. Anderman

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Cross-Desensitization of Chemoattractant Receptors Occurs at Multiple Levels: Evidence for a Role for Inhibition of Phospholipase C Activity, R. M. Richardson, H. Ali, E. D. Tomhave, B. Haribabu, and R. Snyderman