Document Type

Journal Article

Date of this Version

2-2008

Publication Source

Journal of Dental Research

Volume

87

Issue

2

Start Page

107

Last Page

118

DOI

10.1177/154405910808700215

Abstract

Fracture healing and distraction osteogenesis have important applications in orthopedic, maxillofacial, and periodontal treatment. In this review, the cellular and molecular mechanisms that regulate fracture repair are contrasted with bone regeneration that occurs during distraction osteogenesis. While both processes have many common features, unique differences are observed in the temporal appearance and expression of specific molecular factors that regulate each. The relative importance of inflammatory cytokines in normal and diabetic healing, the transforming growth factor beta superfamily of bone morphogenetic mediators, and the process of angiogenesis are discussed as they relate to bone repair. A complete summary of biological activities and functions of various bioactive factors may be found at COPE (Cytokines & Cells Online Pathfinder Encyclopedia), http://www.copewithcytokines.de/cope.cgi.

Comments

At the time of publication, author Dana Graves was affiliated with the Boston University School of Dental Medicine. Currently, he is a faculty member in the Penn Dental School at the University of Pennsylvania.

Keywords

fracture healing, distraction osteogenesis, morphogens, cytokines

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Date Posted: 02 April 2015

This document has been peer reviewed.