Departmental Papers (Dental)
Molecular Mechanisms Controlling Bone Formation During Fracture Healing and Distraction Osteogenesis
Date of this Version
Journal of Dental Research
Fracture healing and distraction osteogenesis have important applications in orthopedic, maxillofacial, and periodontal treatment. In this review, the cellular and molecular mechanisms that regulate fracture repair are contrasted with bone regeneration that occurs during distraction osteogenesis. While both processes have many common features, unique differences are observed in the temporal appearance and expression of specific molecular factors that regulate each. The relative importance of inflammatory cytokines in normal and diabetic healing, the transforming growth factor beta superfamily of bone morphogenetic mediators, and the process of angiogenesis are discussed as they relate to bone repair. A complete summary of biological activities and functions of various bioactive factors may be found at COPE (Cytokines & Cells Online Pathfinder Encyclopedia), http://www.copewithcytokines.de/cope.cgi.
fracture healing, distraction osteogenesis, morphogens, cytokines
Al-Aql, Z. S., Alagl, A. S., Graves, D. T., Gerstenfeld, L. C., & Einhorn, T. A. (2008). Molecular Mechanisms Controlling Bone Formation During Fracture Healing and Distraction Osteogenesis. Journal of Dental Research, 87 (2), 107-118. http://dx.doi.org/10.1177/154405910808700215
Molecular Biology Commons, Osteopathic Medicine and Osteopathy Commons, Periodontics and Periodontology Commons
Date Posted: 02 April 2015
This document has been peer reviewed.
At the time of publication, author Dana Graves was affiliated with the Boston University School of Dental Medicine. Currently, he is a faculty member in the Penn Dental School at the University of Pennsylvania.