Document Type

Journal Article

Date of this Version

9-15-2014

Publication Source

International Journal of Molecular Sciences

Volume

15

Issue

9

Start Page

16257

Last Page

16269

DOI

10.3390/ijms150916257

Abstract

Re-epithelialization is a complex process that involves migration and proliferation of keratinocytes, in addition to the production of cytokines and growth factors that affect other cells. The induction of transcription factors during these processes is crucial for successful wound healing. The transcription factor forkhead boxO-1 (FOXO1) has recently been found to be an important regulator of wound healing. In particular, FOXO1 has significant effects through regulation of transforming growth factor-beta (TGF-β) expression and protecting keratinocytes from oxidative stress. In the absence of FOXO1, there is increased oxidative damage, reduced TGF-β1 expression, reduced migration and proliferation of keratinocytes and increased keratinocytes apoptosis leading to impaired re-epithelialization of wounds.

Copyright/Permission Statement

Copyright © 2014 Alhassan Hameedaldeen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

cell death, epithelial, FOXO, transforming growth factor-beta, migration, proliferation, repair, ROS, skin, wound

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Date Posted: 02 April 2015

This document has been peer reviewed.