Date of this Version
International Journal of Molecular Sciences
Re-epithelialization is a complex process that involves migration and proliferation of keratinocytes, in addition to the production of cytokines and growth factors that affect other cells. The induction of transcription factors during these processes is crucial for successful wound healing. The transcription factor forkhead boxO-1 (FOXO1) has recently been found to be an important regulator of wound healing. In particular, FOXO1 has significant effects through regulation of transforming growth factor-beta (TGF-β) expression and protecting keratinocytes from oxidative stress. In the absence of FOXO1, there is increased oxidative damage, reduced TGF-β1 expression, reduced migration and proliferation of keratinocytes and increased keratinocytes apoptosis leading to impaired re-epithelialization of wounds.
Copyright © 2014 Alhassan Hameedaldeen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
cell death, epithelial, FOXO, transforming growth factor-beta, migration, proliferation, repair, ROS, skin, wound
Hameedaldeen, A., Liu, J., Batres, A., Graves, G. S., & Graves, D. T. (2014). FOXO1, TGF-β Regulation and Wound Healing. International Journal of Molecular Sciences, 15 (9), 16257-16269. http://dx.doi.org/10.3390/ijms150916257
Date Posted: 02 April 2015
This document has been peer reviewed.