Date of this Version
Nucleic Acids Research
Small non-coding RNAs (sncRNAs) are highly abundant RNAs, typically long, that act as key regulators of diverse cellular processes. Although thousands of sncRNA genes are known to exist in the human genome, no single database provides searchable, unified annotation, and expression information for full sncRNA transcripts and mature RNA products derived from these larger RNAs. Here, we present the Database of small human noncoding RNAs (DASHR)
. DASHR contains the most comprehensive information to date on human sncRNA genes and mature sncRNA products. DASHR provides a simple user interface for researchers to view sequence and secondary structure, compare expression levels, and evidence of specific processing across all sncRNA genes and mature sncRNA products in various human tissues. DASHR annotation and expression data covers all major classes of sncRNAs including microRNAs (miRNAs), Piwi-interacting (piRNAs), small nuclear, nucleolar, cytoplasmic (sn-, sno-, scRNAs, respectively), transfer (tRNAs), and ribosomal RNAs (rRNAs). Currently, DASHR (v1.0) integrates 187 smRNA high-throughput sequencing (smRNA-seq) datasets with over 2.5 billion reads and annotation data from multiple public sources. DASHR contains annotations for ~48,000 human sncRNA genes and mature sncRNA products, 82% of which are expressed in one of more of the curated tissues. DASHR is available at http://lisanwanglab.org/DASHR.
This article has published Open Access under a Creative Commons Attribution (CC BY) license.
databases, cytoplasm, genes, genome, human genome, neonatal abstinence syndrome, nucleotides, secondary protein structure, ridbosomes, user-computer interface, RNA, microRNA, transfer technique, primary visual cortex, datasets
Leung, Y. Y., Kuksa, P. P., Amlie-Wolf, A., Valladares, O., Ungar, L. H., Kannan, S., Gregory, B. D., & Wang, L. (2016). DASHR: Database of Small Human Noncoding RNAs. Nucleic Acids Research, 44 (D1), D216-D222. http://dx.doi.org/10.1093/nar/gkv1188
Additional FilesSupplementary_Data_DASHR.zip (1021 kB)
Date Posted: 14 July 2017
This document has been peer reviewed.