Lab-On-A-Chip for Oral Cancer Screening and Diagnosis

Loading...
Thumbnail Image
Penn collection
Departmental Papers (MEAM)
Degree type
Discipline
Subject
oral cancer
lab-on-a-chip
microfluidics
biomarkers
screening
Mechanical Engineering
Funder
Grant number
License
Copyright date
Distributor
Related resources
Author
Mauk, Michael G
Falls, Erica M
Chen, Zongyuan
Ziober, Amy F
Contributor
Abstract

Oral squamous cell carcinoma (OSCC) is a disfiguring and deadly cancer. Despite advances in therapy, many patients continue to face a poor prognosis. Early detection is an important factor in determining the survival of patients with OSCC. No accurate, cost-efficient, and reproducible method exists to screen patients for OSCC. As a result, many patients are diagnosed at advanced stages of the disease. Early detection would identify patients, facilitating timely treatment and close monitoring. Mass screening requires a rapid oral cancer diagnostic test that can be used in a clinical setting. Current diagnostic techniques for OSCC require modern laboratory facilities, sophisticated equipment, and elaborate and lengthy processing by skilled personnel. The lab-on-chip technology holds the promise of replacing these techniques with miniaturized, integrated, automated, inexpensive diagnostic devices. This article describes lab-on-chip devices for biomarker-based identification of oral cancer. Similar methods can be employed for the screening of other types of cancers.

Advisor
Date Range for Data Collection (Start Date)
Date Range for Data Collection (End Date)
Digital Object Identifier
Series name and number
Publication date
2008-01-01
Journal title
Volume number
Issue number
Publisher
Publisher DOI
Journal Issue
Comments
Postprint version. Published in Head and Neck, Volume 30, Issue 1, January 2008, pages 111-121. Publisher URL: http://dx.doi.org/10.1002/hed.20680
Recommended citation
Collection