Epigenetic Changes in the Innate Response of Gingival Epithelium
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Degree type
MSOB (Master of Science in Oral Biology)
Graduate group
Discipline
Subject
periodontitis
innate immunity
TLR2 in Porphyromonas gingivalis recognition
heterogeneity in periodontal disease susceptibility
epigenetics of innate immunity
DNA methylation
Dentistry
Periodontics and Periodontology
innate immunity
TLR2 in Porphyromonas gingivalis recognition
heterogeneity in periodontal disease susceptibility
epigenetics of innate immunity
DNA methylation
Dentistry
Periodontics and Periodontology
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Abstract
In this study we showed TLR2 CpG promoter methylation in periodontitis affected human gingival tissues and in primary human gingival epithelial cells chronically stimulated with P. gingivalis that may instigate epithelial dysbiosis that may create a unique pathogen niche in the gingival crevice and susceptibility to periodontitis.
Advisor
Denis F. Kinane, BDS, PhD
Date of degree
2014-05-28