Departmental Papers (CIS)

Document Type

Journal Article

Subject Area

CPS Medical

Date of this Version



"Challenges and Research Directions in Medical Cyber–Physical Systems," Invited Paper in Special Issue on Cyber-Physical Systems, Proceedings of the IEEE, vol.100, no.1, pp.75-90, Jan. 2012. doi: 10.1109/JPROC.2011.2165270


Medical cyber-physical systems (MCPS) are lifecritical, context-aware, networked systems of medical devices. These systems are increasingly used in hospitals to provide highquality continuous care for patients. The need to design complex MCPS that are both safe and effective has presented numerous challenges, including achieving high assurance in system software, intoperability, context-aware intelligence, autonomy, security and privacy, and device certifiability. In this paper, we discuss these challenges in developing MCPS, some of our work in addressing them, and several open research issues


cyber-physical systems, model-based design, medical device systems, closed-loop physiological control, design challenges



Date Posted: 12 March 2012

This document has been peer reviewed.