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In this paper we introduce our new tool BIOSKETCHPAD that allows visual programming and modeling of biological regulatory networks. The tool allows biologists to create dynamic models of networks using a menu of icons, arrows, and pop-up menus, and translates the input model into CHARON, a modeling language for modular design of interacting multi-agent hybrid systems. Hybrid systems are systems that are characterized by continuous as well as discrete dynamics. Once a CHARON model of the underlying system is generated, we are able to exploit the various analysis capabilities of the CHARON toolkit, including simulation and reachability analysis. We illustrate the advantages of this approach using a case study concerning the regulation of bioluminescence in a marine bacterium.
Rajeev Alur, Calin Belta, Franjo Ivancic, R. Vijay Kumar, Harvey Rubin, Jonathan Schug, Oleg Sokolsky, and Jonathan Webb, "Visual Programming for Modeling and Simulation of Biomolecular Regulatory Networks", . December 2002.
Date Posted: 11 September 2005