Departmental Papers (BE)

Document Type

Journal Article

Date of this Version

March 2007

Abstract

In this study, our phenotype of interest is meiotic recombination. Using genotypes of approximately ~6,000 SNP markers in members of the Centre d'Etude du Polymorphisme Humain Utah pedigrees, we found extensive individual variation in the number of female and male recombination events. The locations and frequencies of these recombination events vary along the genome. In both female and male meiosis, the regions with the most recombination events are found at the ends of the chromosomes. Our analysis also shows that there are polymorphic differences among individuals in the activity of the recombination "jungles"; these preferred sites of meiotic recombination differ greatly among individuals. These findings have important implications for understanding genetic disorders that result from improper chromosome segregation.

Comments

Published in American Journal of Human Genetics, Volume 80, Issue 3, March 2007, pages 526-530.
Publisher URL: http://dx.doi.org/10.1086/512131

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Date Posted: 10 April 2007

This document has been peer reviewed.