Departmental Papers (BE)

Document Type

Conference Paper

Date of this Version

October 2001

Comments

Copyright 2001 IEEE. Reprinted from Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2001 Volume 1, pages 796-801.
Publisher URL: http://ieeexplore.ieee.org/xpl/tocresult.jsp?isNumber=21918&page=15

This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Pennsylvania's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.

Abstract

The Nucleus Accumbens (Nacc) receives convergent input from a number of structures including prefrontal cortex, hippocampus, and amygdala, as well as substantial dopaminergic modulation. The principle cell in the Nacc, the medium spiny projection neuron (MSP), has bistable properties that have been proposed as a primary mediator of the integrative properties in the Nacc. In order to determine the minimum biophysical properties required to generate a nonlinear "bistable" membrane potential, we constructed a 29 compartment MSP cell in GENESIS. This included an inward rectifying K+ (KIR), an A-current K+, HVA Ca2+ and suitable fast Na+ and delayed rectifier K+ channels. Various amounts and distributions of afferent input were examined to determine the amount of coincident input required to move the membrane from the "down" state (-85 mV) to the "up" state (-60 mV) and to fire the cell. The number of synchronous afferents required was substantially higher than previously estimated. We modeled the effect of dopaminergic modulation by increasing the conductance of the KIR and Ca2+ channels, demonstrating that the response to input is dependent on state.

In parallel studies, in vivo extracellular recordings were obtained from Nacc and neocortex in anesthetized mice. Simultaneous recordings revealed that cortex and Nacc oscillate in synchrony. Lesions that disrupt slow oscillations in the cortex alter rhythmicity in the Nacc, suggesting interdependency of the mechanisms generating bistability.

Keywords

Nucleus Accumbens, modeling, medium spiny neurons, in vivo, electrophysiology

Share

COinS
 

Date Posted: 20 November 2004

This document has been peer reviewed.