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There is a long history and a growing interest in the canine as a subject of study in neuroscience research and in translational neurology. In the last few years, anatomical and functional magnetic resonance imaging (MRI) studies of awake and anesthetized dogs have been reported. Such efforts can be enhanced by a population atlas of canine brain anatomy to implement group analyses. Here we present a canine brain atlas derived as the diffeomorphic average of a population of fifteen mesaticephalic dogs. The atlas includes: 1) A brain template derived from in-vivo, T1-weighted imaging at 1 mm isotropic resolution at 3 Tesla (with and without the soft tissues of the head); 2) A co-registered, high-resolution (0.33 mm isotropic) template created from imaging of ex-vivo brains at 7 Tesla; 3) A surface representation of the gray matter/white matter boundary of the high-resolution atlas (including labeling of gyral and sulcal features). The properties of the atlas are considered in relation to historical nomenclature and the evolutionary taxonomy of the Canini tribe. The atlas is available for download (https://cfn.upenn.edu/aguirre/wiki/public:data_plosone_2012_datta).
© 2012 Datta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
canine, neuroscience, magnetic resonance imaging (MRI), anesthetized dogs, taxonomy, Canini
Datta, R., Lee, J., Duda, J., Avants, B. B., Vite, C. H., Tseng, B., Gee, J. C., Aguirre, G. D., & Aguirre, G. K. (2012). A Digital Atlas of the Dog Brain. PLoS ONE, 7 (12), e52140-. http://dx.doi.org/10.1371/journal.pone.0052140
Date Posted: 23 October 2014
This document has been peer reviewed.