Document Type

Journal Article

Date of this Version

12-20-2012

Publication Source

PLoS ONE

Volume

7

Issue

12

Start Page

e52140

DOI

10.1371/journal.pone.0052140

Abstract

There is a long history and a growing interest in the canine as a subject of study in neuroscience research and in translational neurology. In the last few years, anatomical and functional magnetic resonance imaging (MRI) studies of awake and anesthetized dogs have been reported. Such efforts can be enhanced by a population atlas of canine brain anatomy to implement group analyses. Here we present a canine brain atlas derived as the diffeomorphic average of a population of fifteen mesaticephalic dogs. The atlas includes: 1) A brain template derived from in-vivo, T1-weighted imaging at 1 mm isotropic resolution at 3 Tesla (with and without the soft tissues of the head); 2) A co-registered, high-resolution (0.33 mm isotropic) template created from imaging of ex-vivo brains at 7 Tesla; 3) A surface representation of the gray matter/white matter boundary of the high-resolution atlas (including labeling of gyral and sulcal features). The properties of the atlas are considered in relation to historical nomenclature and the evolutionary taxonomy of the Canini tribe. The atlas is available for download (https://cfn.upenn.edu/aguirre/wiki/public:data_plosone_2012_datta).

Copyright/Permission Statement

© 2012 Datta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Comments

Correction: A Digital Atlas of the Dog Brain

DOI: 10.1371/annotation/3cb115c6-d2bb-4d11-b52f-71d1a3a6852d

Additional National Eye Institute/National Institute Health grants to the eighth author were incorrectly omitted from the Funding Statement. The Funding Statement should read: "This work was supported by a Burroughs-Wellcome Career development award to GKA, grants from the Hope for Vision foundation to GDA and GKA, a grant from the Pennsylvania Lion’s Foundation to GKA, National Eye Institute (NEI) / National Institutes of Health (NIH) grants EY020516 (GKA), -06855 (GDA), and -14579 (GDA), Foundation Fighting Blindness (GDA), and the ONCE International Price for R&D in Biomedicine and New Technologies for the Blind (GDA, GKA). GDA also supported by National Eye Institute (NEI) / National Institutes of Health (NIH) grants EY019304 and EY018241. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."

Keywords

canine, neuroscience, magnetic resonance imaging (MRI), anesthetized dogs, taxonomy, Canini

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Date Posted: 23 October 2014

This document has been peer reviewed.