Date of this Version
American Journal of Pathology
Five cats with feline α-L-iduronidase-deficient mucopolysaccharidosis were studied. Membrane-bound cytoplasmic inclusions were present in central nervous system neurons, hepatocytes, chondrocytes, vascular and splenic smooth muscle cells, bone marrow leukocytes, and fibroblasts of the skin, eye, and cardiac valves. The lesions in these cats closely resemble those described in human patients with mucopolysaccharidosis I H (Hurler syndrome).
Reproduced from Am J Pathol 1983, 112 (1): 27-36 with permission from the American Society for Investigative Pathology. The archived version of this article can also be found online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916323/
Haskins, M. E., Aguirre, G. D., Jezyk, P. F., Desnick, R. J., & Patterson, D. F. (1983). The Pathology of the Feline Model of Mucopolysaccharidosis I. American Journal of Pathology, 112 (1), 27-36. Retrieved from https://repository.upenn.edu/vet_papers/22
Date Posted: 20 August 2013
This document has been peer reviewed.