At Penn Vet, we think differently about veterinary medicine.

In addition to providing sophisticated medical treatments for animals of every size and kind, we believe veterinarians play an integral part in ensuring public health and food safety at both local and global levels, recognizing and controlling foreign and newly emerging diseases of livestock and poultry, including diseases transmissible from animals to people.

Our mission comprises teaching, healing, and scientific investigation. We believe that as veterinarians, we not only practice medicine and conduct groundbreaking research to advance all medicine, we teach the next generation to do the same.

We believe future veterinarians should serve as the frontline, guarding against bio- and agro-terrorism and working to protect the environment, all the while advancing the forefront of biomedical research. At Penn Vet, we lead the way for veterinarians of tomorrow.

Follow


Papers from 2018

PDF

BEST1 Gene Therapy Corrects a Diffuse Retina-Wide Microdetachment Modulated by Light Exposure, Karina E. Guziewicz, Artur V. Cideciyan, William A. Beltran, András M. Komáromy, Valerie L. Dufour, Malgorzata Swider, Simone Iwabe, Alexander Sumaroka, Brian T. Kendrick, Gordon Ruthel, Vince A. Chiodo, Elise Heon, William W. Hauswirth, Samuel G. Jacobson, and Gustavo D. Aguirre

Papers from 2017

PDF

Concepts and Strategies in Retinal Gene Therapy, Gustavo D. Aguirre

PDF

Strong Upregulation of Inflammatory Genes Accompanies Photoreceptor Demise in Canine Models of Retinal Degeneration, Tatyana Appelbaum, Evelyn Santana, and Gustavo D. Aguirre

PDF

Variabilities in Retinal Function and Structure in a Canine Model of Cone-Rod Dystrophy Associated With RPGRIP1 Support Multigenic Etiology, Rueben G. Das, Felipe P. Marinho, Simone Iwabe, Evelyn Santana, Kendra S. McDaid, Gustavo D. Aguirre, and Keiko Miyadera

PDF

Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration, Raghavi Sudharsan, Daniel P. Beiting, Gustavo D. Aguirre, and William A. Beltran

PDF

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa, Raghavi Sudharsan, Kristina M. Simone, Nathan P. Anderson, Gustavo D. Aguirre, and William A. Beltran

Papers from 2016

PDF

Molecular Studies of Phenotype Variation in Canine RPGR-XLPRA1, Tatyana Appelbaum, Doreen Becker, Evelyn Santana, and Gustavo D. Aguirre

PDF

Assessing U.S. Food Wastage and Opportunities for Reduction, Zhengxia Dou, James D. Ferguson, David T. Galligan, Alan M. Kelly, Steven M. Finn, and Robert Giegengack

PDF

Photoreceptor Proliferation and Dysregulation of Cell Cycle Genes in Early Onset Inherited Retinal Degenerations, Kristin L. Gardiner, Louise Downs, Agnes I. Berta-Antalics, Evelyn Santana, Gustavo D. Aguirre, and Sem Genini

PDF

Assessment of Visual Function and Retinal Structure Following Acute Light Exposure in the Light Sensitive T4R Rhodopsin Mutant Dog, Simone Iwabe, Gui-shuang Ying, Gustavo D. Aguirre, and William A. Beltran

Papers from 2015

PDF

Successful Arrest of Photoreceptor and Vision Loss Expands the Therapeutic Window of Retinal Gene Therapy to Later Stages of Disease, William A. Beltran, Artur V. Cideciyan, Simone Iwabe, Malgorzata Swider, Mychajlo S. Kosyk, Kendra S. McDaid, Inna Martynyuk, Gui-shuang Ying, James Shaffer, Wen-Tao Deng, Sanford L. Boye, Alfred S. Lewin, William W. Hauswirth, Samuel G. Jacobson, and Gustavo D. Aguirre

PDF

Improvement in Vision: A New Goal for Treatment of Hereditary Retinal Degenerations, Samuel G. Jacobson, Artur V. Cideciyan, Gustavo D. Aguirre, Alejandro J. Roman, Alexander Sumaroka, William W. Hauswirth, and Krzysztof Palczewski

PDF

A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness, Mineo Kondo, Guatami Das, Ryoetsu Imai, Evelyn Santana, Tomio Nakashita, Miho Imawaka, Kosuke Ueda, Hirohiko Ohtsuka, Kazuhiko Sakai, Takehiro Aihara, Kumiko Kato, Masahiko Sugimoto, Shinji Ueno, Yuji Nishizawa, Gustavo D. Aguirre, and Keiko Miyadera

PDF

Exclusion of the Unfolded Protein Response in Light-Induced Retinal Degeneration in the Canine T4R RHO Model of Autosomal Dominant Retinitis Pigmentosa, Stefania Marsilli, Sem Genini, Raghavi Sudharsan, Jeremy Gingrich, Gustavo D. Aguirre, and William Beltran

PDF

Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration, Ruchira Singh, David Kuai, Karina E. Guziewicz, Jackelyn Meyer, Molly Wilson, Jianfeng Lu, Molly Smith, Eric Clark, Amelia Verhoeven, Gustavo D. Aguirre, and David M. Gamm

PDF

Canine CNGA3 Gene Mutations Provide Novel Insights Into Human Achromatopsia-Associated Channelopathies and Treatment, Naoto Tanaka, Emily V. Dutrow, Keiko Miyadera, Lucie Delemotte, Christopher M. MacDermaid, Shelby L. Reinstein, William R. Crumley, Christopher J. Dixon, Margret L. Casal, Michael L. Klein, Gustavo D. Aguirre, Jacqueline C. Tanaka, and Karina E. Guziewicz

Papers from 2014

PDF

Pigmentary Uveitis, Gustavo D. Aguirre

PDF

Canine Retina Has a Primate Fovea-Like Bouquet of Cone Photoreceptors Which Is Affected by Inherited Macular Degenerations, William Beltran, Artur V. Cideciyan, Karina E. Guziewicz, Simone Iwabe, Erin M. Scott, Svetlana V. Savina, Gordon Ruthel, Frank Stefano, Lingli Zhang, Richard Zorger, Alexander Sumaroka, Samuel G. Jacobson, and Gustavo D. Aguirre

PDF

Restoration of Visual Function by Expression of a Light-Gated Mammalian Ion Channel in Retinal Ganglion Cells or ON-Bipolar Cells, Benjamin M. Gaub, Michael H. Berry, Amy E. Holt, Andreas Reiner, Michael A. Kienzler, Natalia Dolgova, Sergei Nikonov, Gustavo D. Aguirre, William A. Beltran, John G. Flannery, and Ehud Y. Isacoff

PDF

Altered miRNA Expression in Canine Retinas During Normal Development and in Models of Retinal Degeneration, Sem Genini, Karina E. Guziewicz, William A. Beltran, and Gustavo D. Aguirre

PDF

Non-Equilibrium Dynamics Contribute to Ion Selectivity in the KcsA Channel, Van Ngo, Darko Stefanovski, Stephan Haas, and Robert A. Farley

PDF

Non-Equilibrium Dynamics Contribute to Ion Selectivity in the KcsA Channel, Van Ngo, Darko Stefanovski, Stephen Haas, and Robert A. Farley

Papers from 2013

PDF

Reply to Townes-Anderson: RPE65 Gene Therapy Does Not Alter the Natural History of Retinal Degeneration, Artur V. Cideciyan, Samuel G. Jacobson, William A. Beltran, William W. Hauswirth, and Gustavo D. Aguirre

PDF

Human Retinal Gene Therapy for Leber Congential Amaurosis Shows Advancing Retinal Degeneration Despite Enduring Visual Improvement, Artur V. Cideciyan, Samuel G. Jacobson, William A. Beltran, Alexander Sumaroka, Malgorzata Swider, Simone Iwabe, Alejandro J. Roman, Melani B. Olivares, Sharon B. Schwartz, András M. Komáromy, William W. Hauswirth, and Gustavo D. Aguirre

PDF

Blinded by the Light: Retinal Phototoxicity in the Context of Safety Studies, Maria Cristina De Vera Mudry, Sven Kronenberg, Shun-ichiro Komatsu, and Gustavo D. Aguirre

PDF

Up-Regulation of Tumor Necrosis Factor Superfamily Genes in Early Phases of Photoreceptor Degeneration, Sem Genini, William Beltran, and Gustavo D. Aguirre

PDF

A Non-Stop S-Antigen Gene Mutation Is Associated With Late Onset Hereditary Retinal Degeneration in Dogs, Orly Goldstein, Julie Ann Jordan, Gustavo D. Aguirre, and Gregory M. Acland

PDF

IQCB1 and PDE6B Mutations Cause Similar Early Onset Retinal Degenerations in Two Closely Related Terrier Dog Breeds, Orly Goldstein, Jason G. Mezey, Peter A. Schweitzer, Adam R. Boyko, Chuan Gao, Carlos D. Bustamante, Julie A. Jordan, Gustavo D. Aguirre, and Gregory M. Acland

PDF

Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects, Karina E. Guziewicz, Barbara Zangerl, András M. Komáromy, Simone Iwabe, Vincent A. Chiodo, Sanford L. Boye, William W. Hauswirth, William Beltran, and Gustavo D. Aguirre

PDF

Transient Photoreceptor Deconstruction by CNTF Enhances rAAV-Mediated Cone Functional Rescue in Late Stage CNGB3-Achromatopsia, András M. Komáromy, Jessica S. Rowlan, Amanda T. Parton Corr, Shelby L. Reinstein, Sanford L. Boye, Ann E. Cooper, Amaliris Gonzalez, Britt Levy, Rong Wen, William W. Hauswirth, William A. Beltran, and Gustavo D. Aguirre

PDF

Components of Metabolic Syndrome and 5-Year Chance in Insulin Clearance - The Resistance Atherosclerosis Study (IRAS), C. Christine Lee, Carlos Lorenzo, Steven M. Haffner, Lynne E. Wagenknecht, Mark O. Goodarzi, Darko Stefanovski, Jill M. Norris, Marian J. Rewers, and Anthony J. Hanley

PDF

FGF19 Action in the Brain Induces Insulin-Independent Glucose Lowering, Gregory J. Morton, Miles E. Matsen, Deanna P. Bracy, Thomas H. Meek, Hong T. Nguyen, Darko Stefanovski, Richard N. Bergman, David H. Wasserman, and Michael W. Schwartz

PDF

Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion During Acute Sepsis in Non-Diabetic Mice, Yoshio Watanabe, Srikanth Singamsetty, Baobo Zou, Lanping Guo, Darko Stefanovski, Laura C. Alonso, Adolfo Garcia-Ocana, Christopher P. O'Donnell, and Bryan J. McVerry

PDF

Exogenous Glucose Administration Impairs Glucose Tolerance and Pancreatic Insulin Secretion During Acute Sepsis in Non-Diabetic Mice, Yoshio Watanabe, Srikanth Singamsetty, Baobo Zou, Lanping Guo, Darko Stefanovski, Laura C. Alonso, Adolfo Garcia-Ocana, Christopher P. O'Donnell, and Bryan J. McVerry

Papers from 2012

PDF

A Digital Atlas of the Dog Brain, Ritobrato Datta, Jongho Lee, Jeffrey Duda, Brian B. Avants, Charles H. Vite, Ben Tseng, Jim C. Gee, Gustavo D. Aguirre, and Geoffrey K. Aguirre

PDF

Development and Validation of a Canine-Specific Profiling Array to Examine Expression of Pro-Apoptotic and Pro-Survival Genes in Retinal Degenerative Diseases, Sem Genini, William Beltran, and Gustavo D. Aguirre

PDF

Modeling the Structural Consequences of BEST1 Missense Mutations, Karina E. Guziewicz, Gustavo D. Aguirre, and Barbara Zangerl

PDF

Canine Multifocal Retinopathy in the Australian Shepherd: A Case Report, Ingo Hoffmann, Karina E. Guziewicz, Barbara Zangerl, Gustavo D. Aguirre, and Christian Y. Mardin

PDF

OGTT-Derived Measures of Insulin Sensitivity Are Confounded by Factors Other Than Insulin Sensitivity Itself, Katrin Hücking, Richard M. Watanabe, Darko Stefanovski, and Richard N. Bergman

PDF

RPGRIP1 and Cone-Rod Dystrophy in Dogs, Tatyana N. Kuznetsova, Barbara Zangerl, and Gustavo D. Aguirre

PDF

Greater Omentectomy Improves Insulin Sensitivity in Nonobese Dogs, Maya Lottati, Cathryn M. Kolka, Darko Stefanovski, Erlinda L. Kirkman, and Richard N. Bergman

PDF

Genetic and Phenotypic Variations of Inherited Retinal Diseases in Dogs: The Power of Within- and Across-Breed Studies, Keiko Miyadera, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Accelerating the Deactivation of Salmonella enterica Serovar Newport and Escherichia coli O157:H7 in Dairy Manure by Modifying pH or Temperature, John D. Toth, Helen W. Aceto, Shelley C. Rankin, Chitrita DebRoy, and Zhengxia Dou

Papers from 2011

PDF

Evaluation of Adeno-Associated Viral Vectors for Liver-Directed Gene Transfer in Dogs, Peter Bell, Guangping Gao, Mark E. Haskins, Lili Wang, Margaret M. Sleeper, Huan Wang, Roberto Calcedo, Luk H. Vandenberghe, Shu-Jen Chen, Chick Weisse, Elanor Withnall, and James M. Wilson

PDF

A Better Index of Body Adiposity, Richard N. Bergman, Darko Stefanovski, Thomas A. Buchanan, Anne E. Sumner, James C. Reynolds, Nancy G. Sebring, Anny H. Xiang, and Richard M. Watanabe

PDF

Photoreceptor Cell Death, Proliferation and Formation of Hybrid Rod/S-Cone Photoreceptors in the Degenerating STK38L Mutant Retina, Ágnes I. Berta, Kathleen Boesze-Battaglia, Sem Genini, Orly Goldstein, Paul J. O'Brien, Ágoston Szél, Gregory M. Acland, William Beltran, and Gustavo D. Aguirre

PDF

A Kutya Mint Modell az Örökletes Retinadegenerációk Kutatásában / The Dog as a Model in Research Into Inherited Retinal Degenerations, Ágnes I. Berta, Ágoston Szél, and Gustavo D. Aguirre

PDF

Long-Term Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Golden Retriever Muscular Dystrophy, Lawrence T. Bish, Margaret M. Sleeper, Sean C. Forbes, Kevin J. Morine, Caryn A. Reynolds, Gretchen E. Singletary, Dennis Trafny, Jennifer Pham, Janet Bogan, Joe N. Kornegay, Krista Vandenborne, Glenn A. Walter, and H. Lee Sweeney

PDF

Cardiac Gene Transfer of Short Hairpin RNA Directed Against Phospholamban Effectively Knocks Down Gene Expression but Causes Cellular Toxicity in Canines, Lawrence T. Bish, Margaret M. Sleeper, Caryn A. Reynolds, Jeffrey Gazzara, Elanor Withnall, Gretchen E. Singletary, George Buchlis, Daniel Hui, Katherine A. High, Guangping Gao, James M. Wilson, and H. Lee Sweeney

PDF

Chronic Losartan Administration Reduces Mortality and Preserves Cardiac but Not Skeletal Muscle Function in Dystrophic Mice, Lawrence T. Bish, Mark Yarchoan, Margaret M. Sleeper, Jeffrey Gazzara, Kevin J. Morine, Pedro Acosta, Elisabeth R. Barton, and H. Lee Sweeney

PDF

Intraocular Nematodiasis in a Llama (Lama glama), Bettina Dunkel, Raymond W. Sweeney, Perry L. Habecker, and András M. Komáromy

PDF

Transcendocardinal Delivery of AAV6 Results in Highly Efficient and Global Cardiac Gene Transfer in Rhesus Macaques, Guangping Gao, Lawrence T. Bish, Margaret M. Sleeper, Xin Mu, Lan Sun, You Lou, Jiachuan Duan, Chunyan Hu, Li Wang, and H. Lee Sweeney

PDF

Canine Heart Failure - Early Diagnosis, Prompt Treatment, Mark A. Oyama

PDF

Lethargy, Inappetence, & Increased Respiratory Effort in a Cat, Mark A. Oyama

PDF

Consistency of the Disposition Index in the Face of Diet Induced Insulin Resistance: Potential Role of FFA, Darko Stefanovski, Joyce M. Richey, Orison Woolcott, Maya Lottati, Dan Zheng, Lisa N. Harrison, Viorica Ionut, Stella P. Kim, and Richard N. Bergman

PDF

Consistency of the Disposition Index in the Face of Diet Induced Insulin Resistance: Potential Role of FFA, Darko Stefanovski, Joyce M. Richey, Orison Woolcott, Maya Lottati, Dan Zheng, Lisa N. Harrison, Viorica Ionut, Stella P. Kim, Isabel Hsu, and Richard N. Bergman

Papers from 2010

PDF

Window Into Retinal Studies, Gustavo D. Aguirre

PDF

rAAV2/5 Gene-Targeting to Rods: Dose-Dependent Efficiency and Complications Associated With Different Promoters, William Beltran, Sanford L. Boye, Shannon E. Boye, Vince A. Chiodo, Alfred S. Lewin, William W. Hauswirth, and Gustavo D. Aguirre

PDF

Myostatin Is Upregulated Following Stress in an Erk-Dependent Manner and Negatively Regulates Cardiomyocyte Growth in Culture and in a Mouse Model, Lawrence T. Bish, Kevin J. Morine, Margaret M. Sleeper, and H. Lee Sweeney

PDF

COL9A2 and COL9A3 Mutations in Canine Autosomal Recessive Oculoskeletal Dysplasia, Orly Goldstein, Richard Guyon, Anna Kukekova, Tatyana N. Kuznetsova, Susan E. Pearce-Kelling, Jennifer Johnson, Gustavo D. Aguirre, and Gregory M. Acland

PDF

Exonic SINE Insertion in STK38L Causes Canine Early Retinal Degeneration (erd), Orly Goldstein, Anna V. Kukekova, Gustavo D. Aguirre, and Gregory M. Acland

PDF

Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Normal and Dystrophic Mice, Kevin J. Morine, Lawrence T. Bish, Klara Pendrak, Margaret M. Sleeper, Elisabeth R. Barton, and H. Lee Sweeney

PDF

Overexpression of SERCA1a in the mdx Diaphragm Reduces Susceptibility to Contraction-Induced Damage, Kevin J. Morine, Margaret M. Sleeper, Elisabeth R. Barton, and H. Lee Sweeney

PDF

Cardiac N-Terminal Pro-B-Type Natriuretic Peptide Assay, Mark A. Oyama and Gretchen E. Singletary

PDF

Identification of Genetic Variation and Haplotype Structure of the Canine ABCA4 Gene for Retinal Disease Association Studies, Barbara Zangerl, Sarah J. Lindauer, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Assessment of Canine BEST1 Variations Identifies New Mutations and Establishes an Independent Bestrophinopathy Model (cmr3), Barbara Zangerl, Kaisa Wickström, Julianna Slavik, Sarah J. Lindauer, Saija Ahonen, Claude Schelling, Hannes Lohi, Karina E. Guziewicz, and Gustavo D. Aguirre

Papers from 2009

PDF

Age-Dependent Disease Expression Determines Remodeling of the Retinal Mosaic in Carriers of RPGR Exon ORFn15 Mutations, William Beltran, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Steroids Do Not Prevent Photoreceptor Degeneration in the Light-Exposed T4R Rhodopsin Mutant Dog Retina Irrespective of AP-1 Inhibition, Danian Gu, William Beltran, Sue Pearce-Kelling, Zexiao Li, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Canine RD3 Mutation Establishes Rod-Cone Dysplasia Type 2 (rcd2) as Ortholog of Human and Murine rd3, Anna V. Kukekova, Orly Goldstein, Jennifer L. Johnson, Malcolm A. Richardson, Susan E. Pearce-Kelling, Anand Swaroop, James S. Friedman, Gustavo D. Aguirre, and Gregory M. Acland

PDF

Bovine Cardiac Troponin I Gene (TNNI3) as a Candidate Gene for Bovine Dilated Cardiomyopathy, Marta Owczarek-Lipska, Gaudenz Dolf, Karina E. Guziewicz, Tosso Leeb, Claude Shelling, Horst Posthaus, and Martin H. Braunschweig

PDF

Cardiac Drugs for Treatment of Canine Heart Failure, Mark A. Oyama

PDF

Comparative Genomic Mapping of Uncharacterized Canine Retinal ESTs to Identify Novel Candidate Genes for Hereditary Retinal Disorders, Barbara Zangerl, Jennifer L. Johnson, Jarek Pillardy, Qi Sun, Catherine André, Francis Galibert, Gregory M. Acland, and Gustavo D. Aguirre

Papers from 2008

PDF

Adeno-Assocated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat, Lawrence T. Bish, Kevin J. Morine, Margaret M. Sleeper, Julio Sanmiguel, Di Wu, Guangping Gao, James M. Wilson, and H. Lee Sweeney

PDF

Drug Delivery to Posterior Intraocular Tissues: Third Annual ARVO/Pfizer Ophthalmics Research Institute Conference, Henry F. Edelhauser, Jeffrey H. Boatright, John M. Nickerson, Third ARVO/Pfizer Research Institute Working Group, and Gustavo D. Aguirre

PDF

Operating in the Dark: A Night-Vision System for Surgery in Retinas Susceptible to Light Damage, András M. Komáromy, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Targeting Gene Expression to Cones With Human Cone Opsin Promoters in Recombinant AAV, András M. Komáromy, John J. Alexander, Anne E. Cooper, Vince A. Chodo, Gregory M. Acland, William W. Hauswirth, and Gustavo D. Aguirre

PDF

Cardiac Disorder in a Cat, Caryn A. Reynolds, Mark A. Oyama, and Sonya G. Gordon

PDF

Exploring Human/Animal Intersections: Converging Lines of Evidence in Comparative Models of Aging, John Q. Trojanowski, Joan C. Hendricks, Kathryn Jedrziewski, F. Brad Johnson, Kathryn E. Michel, Rebecka S. Hess, Michael P. Cancro, Margaret M. Sleeper, Robert Pignolo, Karen L. Teff, Gustavo D. Aguirre, Virginia Man-Yee Lee, Dennis F. Lawler, Allan I. Pack, and Peter F. Davies

Papers from 2007

PDF

Canine and Human Visual Cortex Intact and Responsive Despite Early Retinal Blindness from RPE65 Mutation, Geoffrey K. Aguirre, András M. Komáromy, Artur V. Cideciyan, David H. Brainard, Tomas S. Aleman, Alejandro J. Roman, Brian B. Avants, James C. Gee, Marc Korczykowski, William W. Hauswirth, Gregory M. Acland, Gustavo D. Aguirre, and Samuel G. Jacobson

PDF

Intravitreal Injection of Ciliary Neurotrophic Factor (CNTF) Causes Peripheral Remodeling and Does Not Prevent Photoreceptor Loss in Canine RPGR Mutant Retina, William Beltran, Rong Wen, Gregory M. Acland, and Gustavo D. Aguirre

PDF

AKA-TPG: A Program for Kinetic and Epidemiological Analysis of Data from Labeled Glucose Investigations Using the Two-Pool Model and Database Technology, Raymond C. Boston, Darko Stefanovski, Jan E. Henriksen, Glen M. Ward, and Peter J. Moate

PDF

Bone Marrow Transplantation for Feline Mucopolysaccharidosis I, Norman Matthew Ellinwood, Marie-Anne Colle, Margaret A. Weil, Margret L. Casal, Charles H. Vite, Staci Wiemelt, Christopher W. Hasson, Thomas M. O'Malley, Xingxuan He, Ulana Prociuk, Lucie Verot, John R. Melniczek, Anne Lannon, Gustavo D. Aguirre, Van W. Knox, Sydney M. Evans, Marie T. Vanier, Edward H. Schuchman, Steven U. Walkley, and Mark E. Haskins

PDF

Clinical Light Exposure, Photoreceptor Degeneration, and AP-1 Activation: A Cell Death or Cell Survival Signal in the Rhodopsin Mutant Retina?, Danian Gu, William Beltran, Zexiao Li, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Analysis of Six Candidate Genes as Potential Modifiers of Disease Expression in Canine XLPRA1, a Model for Human X-Linked Retinitis Pigmentosa 3, Richard Guyon, Susan E. Pearce-Kelling, Caroline J. Zeiss, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Bestrophin Gene Mutations Cause Canine Multifocal Retinopathy: A Novel Animal Model for Best Disease, Karina E. Guziewicz, Barbara Zangerl, Sarah J. Lindauer, Robert F. Mullins, Lynne S. Sandmeyer, Bruce H. Grahn, Edwin M. Stone, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Cloning and Characterization of Canine PAX6 and Evaluation as a Candidate Gene in a Canine Model of Aniridia, Linda S. Hunter, Duska J. Sidjanin, Manuel Villagrasa Hijar, Jennifer L. Johnson, Ewen Kirkness, Gregory M. Acland, and Gustavo D. Aguirre

PDF

A Meiotic Linkage Map of the Silver Fox, Aligned and Compared to the Canine Genome, Anna V. Kukekova, Lyudmila N. Trut, Irina N. Oskina, Jennifer L. Johnson, Svetlana V. Temnykh, Anastasiya V. Kharlamova, Darya V. Shepeleva, Rimma G. Gulievich, Svetlana G. Shikhevich, Alexander S. Graphodatsky, Gustavo D. Aguirre, and Gregory M. Acland

PDF

Breed Relationships Facilitate Fine-Mapping Studies: A 7.8-kb Deletion Cosegregates With Collie Eye Anomaly Across Multiple Dog Breeds, Heidi G. Parker, Anna V. Kukekova, Danya T. Akey, Orly Goldstein, Ewen F. Kirkness, Kathleen C. Baysac, Dana S. Mosher, Gustavo D. Aguirre, Gregory M. Acland, and Elaine A. Ostrander

Papers from 2006

PDF

Linkage Disequilibrium Mapping in Domestic Dog Breeds Narrows the Progressive Rod-Cone Degeneration Interval and Identifies Ancestral Disease-Transmitting Chromosome, Orly Goldstein, Barbara Zangerl, Sue Pearce-Kelling, Duska J. Sidjanin, James W. Kijas, Jeanette Felix, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Radiation Hybrid Mapping of Cataract Genes in the Dog, Linda S. Hunter, Duska J. Sidjanin, Jennifer L. Johnson, Barbara Zangerl, Francis Galibert, Catherine Andre, Ewen Kirkness, Elijah Talamas, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Safety in Nonhuman Primates of Ocular AAV2-RPE65, a Candidate Treatment for Blindness in Leber Congenital Amaurosis, Samuel G. Jacobson, Sanford L. Boye, Tomas S. Aleman, Thomas J. Conlon, Caroline J. Zeiss, Alejandro J. Roman, Artur V. Cideciyan, Sharon B. Schwartz, András M. Komáromy, Michelle Doobrajh, Andy Y. Cheung, Alexandar Sumaroka, Susan E. Pearce-Kelling, Gustavo D. Aguirre, Shalesh Kaushal, Albert M. Maguire, Terence R. Flotte, and William W. Hauswirth

PDF

Application of a New Subretinal Injection Device in the Dog, András M. Komáromy, Signe E. Varner, Eugene de Juan, Gregory M. Acland, and Gustavo D. Aguirre

PDF

Dimensional Analysis of MINMOD Leads to Definition of the Disposition Index of Glucose Regulation and Improved Simulation Algorithm, Aparna Nittala, Soumitra Ghosh, Darko Stefanovski, Richard Bergman, and Xujing Wang

PDF

Characterization of Gene Expression Profiles of Normal Canine Retina and Brain Using a Retinal cDNA Microarray, Gerardo L. Paez, Kimberly F. Sellers, Mark Band, Gregory M. Acland, Barbara Zangerl, and Gustavo D. Aguirre

PDF

Identical Mutation in a Novel Retinal Gene Causes Progressive Rod-Cone Degeneration in Dogs and Retinitis Pigmentosa in Humans, Barbara Zangerl, Orly Goldstein, Alisdair R. Philip, Sarah J. P Lindauer, Susan E. Pearce-Kelling, Roberts F. Mullins, Alexander S. Graphodatsky, Daniel Ripoll, Jeanette S. Felix, Edwin M. Stone, Gregory M. Acland, and Gustavo D. Aguirre

Papers from 2005

PDF

Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness, Gregory M. Acland, Gustavo D. Aguirre, Jean Bennett, Tomas S. Aleman, Artur V. Cideciyan, Jeannette Bennicelli, Nadine S. Dejneka, Susan E. Pearce-Kelling, Albert M. Maguire, Krzysztof Palczewski, William W. Hauswirth, and Samuel G. Jacobson

PDF

Immunolocalization of Ciliary Neurotrophic Factor Receptor α (CNTFRα) in Mammalian Photoreceptor Cells, William Beltran, Hermann Rohrer, and Gustavo D. Aguirre

PDF

Cloning of Canine Galactokinase (GALK1) and Evaluation as a Candidate Gene for Hereditary Cataracts in Labrador Retrievers, Duska J. Sidjanin, John L. McElwee, Brian Miller, and Gustavo D. Aguirre

Papers from 2004

PDF

Acute Vascular Occlusion in Horses: Effects on Skeletal Muscle Size and Blood Flow, Takashi Abe, Charles F. Kearns, Hélio C. Manso Filho, Yoshiaki Sato, Margaret M. Sleeper, and Kenneth H. McKeever

PDF

MINMOD Millennium: A Computer Program to Calculate Glucose Effectiveness and Insulin Sensitivity From the Frequently Sampled Intravenous Glucose Tolerance Test, Ray C. Boston, Darko Stefanovski, Peter J. Moate, Anne E. Sumner, Richard M. Watanabe, and Richard N. Bergman