Statistics Papers

Document Type

Technical Report

Date of this Version

2-2015

Publication Source

Journal of Behavioral Medicine

Volume

38

Issue

1

Start Page

39

Last Page

47

DOI

10.1007/s10865-014-9576-3

Abstract

This study examined whether longitudinal adherence profiles mediated the relationship between a brief adherence intervention and glycemic control among patients with type 2 diabetes. Adherence was assessed using the Medication Event Monitoring System. Longitudinal analysis via growth curve mixture modeling was carried out to classify patients according to patterns of adherence to oral hypoglycemic agents. Hemoglobin A1c assays were used to measure glycemic control as the clinical outcome. Across the whole sample, longitudinal adherence profiles mediated 35.2% (13.2, 81.0%) of the effect of a brief adherence intervention on glycemic control [from odds ratio (OR) = 8.48, 95% confidence interval (CI) (3.24, 22.2) to 4.00, 95% CI (1.34, 11.93)]. Our results suggest that patients in the intervention had better glycemic control largely due to their greater likelihood of adherence to oral hypoglycemic agents.

Copyright/Permission Statement

This is a post-peer-review, pre-copyedit version of an article published in Journal of Behavioral Medicine. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10865-014-9576-3

Keywords

primary health care, type 2 diabetes, adherence, randomized controlled trials, mediation

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Date Posted: 25 October 2018

This document has been peer reviewed.