Date of this Version
Journal of Behavioral Medicine
This study examined whether longitudinal adherence profiles mediated the relationship between a brief adherence intervention and glycemic control among patients with type 2 diabetes. Adherence was assessed using the Medication Event Monitoring System. Longitudinal analysis via growth curve mixture modeling was carried out to classify patients according to patterns of adherence to oral hypoglycemic agents. Hemoglobin A1c assays were used to measure glycemic control as the clinical outcome. Across the whole sample, longitudinal adherence profiles mediated 35.2% (13.2, 81.0%) of the effect of a brief adherence intervention on glycemic control [from odds ratio (OR) = 8.48, 95% confidence interval (CI) (3.24, 22.2) to 4.00, 95% CI (1.34, 11.93)]. Our results suggest that patients in the intervention had better glycemic control largely due to their greater likelihood of adherence to oral hypoglycemic agents.
This is a post-peer-review, pre-copyedit version of an article published in Journal of Behavioral Medicine. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10865-014-9576-3
primary health care, type 2 diabetes, adherence, randomized controlled trials, mediation
de Vries McClintock, H. F., Morales, K. H., Small, D. S., & Bogner, H. R. (2015). A Brief Adherence Intervention that Improved Glycemic Control: Mediation by Patterns of Adherence. Journal of Behavioral Medicine, 38 (1), 39-47. http://dx.doi.org/10.1007/s10865-014-9576-3
Date Posted: 25 October 2018
This document has been peer reviewed.