Date of this Version
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Markov models are extensively used in the analysis of molecular evolution. A recent line of research suggests that pairs of proteins with functional and physical interactions co-evolve with each other. Here, by analyzing hundreds of orthologous sets of three fungi and their co-evolutionary relations, we demonstrate that co-evolutionary assumption may violate the Markov assumption. Our results encourage developing alternative probabilistic models for the cases of extreme co-evolution.
Markov processes, biological techniques, biology computing, genetics, microorganisms, molecular biophysics, Markov assumption, Markov models, fungi, phylogenetics, probabilistic models, computational biology, co-evolution, models of molecular evolution, phylogenetic reconstruction, animals, evolution, molecular, humans, Markov chains, phylogeny, proteins
Tuller, T., & Mossel, E. (2011). Co-evolution Is Incompatible With the Markov Assumption in Phylogenetics. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 8 (6), 1667-1670. http://dx.doi.org/10.1109/TCBB.2010.124
Date Posted: 27 November 2017
This document has been peer reviewed.