Statistics Papers

Document Type

Journal Article

Date of this Version

11-2011

Publication Source

IEEE/ACM Transactions on Computational Biology and Bioinformatics

Volume

8

Issue

6

Start Page

1667

Last Page

1670

DOI

10.1109/TCBB.2010.124

Abstract

Markov models are extensively used in the analysis of molecular evolution. A recent line of research suggests that pairs of proteins with functional and physical interactions co-evolve with each other. Here, by analyzing hundreds of orthologous sets of three fungi and their co-evolutionary relations, we demonstrate that co-evolutionary assumption may violate the Markov assumption. Our results encourage developing alternative probabilistic models for the cases of extreme co-evolution.

Keywords

Markov processes, biological techniques, biology computing, genetics, microorganisms, molecular biophysics, Markov assumption, Markov models, fungi, phylogenetics, probabilistic models, computational biology, co-evolution, models of molecular evolution, phylogenetic reconstruction, animals, evolution, molecular, humans, Markov chains, phylogeny, proteins

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Date Posted: 27 November 2017

This document has been peer reviewed.