Statistics Papers

Document Type

Journal Article

Date of this Version

2012

Publication Source

The Annals of Applied Statistics

Volume

6

Issue

2

Start Page

476

Last Page

496

DOI

10.1214/11-AOAS517

Abstract

We propose a flexible change-point model for inhomogeneous Poisson Processes, which arise naturally from next-generation DNA sequencing, and derive score and generalized likelihood statistics for shifts in intensity functions. We construct a modified Bayesian information criterion (mBIC) to guide model selection, and point-wise approximate Bayesian confidence intervals for assessing the confidence in the segmentation. The model is applied to DNA Copy Number profiling with sequencing data and evaluated on simulated spike-in and real data sets.

Keywords

copy number, CNV, change point, inhomogeneous Poisson process, point-wise confidence interval

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Date Posted: 27 November 2017

This document has been peer reviewed.